EMPA
- Product Name
- EMPA
- CAS No.
- 680590-49-2
- Chemical Name
- EMPA
- Synonyms
- EMPA, CID 9981404;Hypocretin Receptor,EMPA,Orexin Receptor (OX Receptor),HCRT Receptor,inhibit,Inhibitor;N-Ethyl-2-((N-(6-methoxypyridin-3-yl)-2-methylphenyl)sulfonamido)-N-(pyridin-3-ylmethyl)acetamide;N-ETHYL-2-[(6-METHOXYPYRIDIN-3-YL)-(2-METHYLPHENYL)SULFONYLAMINO]-N-(PYRIDIN-3-YLMETHYL)ACETAMIDE;N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide;Acetamide, N-ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-
- CBNumber
- CB32695845
- Molecular Formula
- C23H26N4O4S
- Formula Weight
- 454.54
- MOL File
- 680590-49-2.mol
EMPA Property
- Boiling point:
- 660.7±65.0 °C(Predicted)
- Density
- 1.280±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble to 100 mM in DMSO and to 100 mM in ethanol
- form
- Powder
- pka
- 4.77±0.10(Predicted)
- color
- white to light brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0864
- Product name
- EMPA
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $132
- Updated
- 2024/03/01
- Product number
- SML0864
- Product name
- EMPA
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $430
- Updated
- 2024/03/01
- Product number
- 29446
- Product name
- EMPA
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 29446
- Product name
- EMPA
- Packaging
- 10mg
- Price
- $186
- Updated
- 2024/03/01
- Product number
- E521550
- Product name
- EMPA
- Packaging
- 100mg
- Price
- $1210
- Updated
- 2021/12/16
EMPA Chemical Properties,Usage,Production
Description
EMPA is an orexin 2 receptor (OX2R) antagonist (Ki = 1.1 nM). It is selective for OX2R over OX1R (Ki = 900 nM). EMPA inhibits orexin-A- and orexin-B-induced calcium mobilization (IC50s = 8.8 and 7.9 nM, respectively) and increases orexin-A- and orexin-B-induced inositol phosphate accumulation (EC50s = 1.1 and 2.4 nM, respectively) in CHO(dHFr-) cells expressing recombinant human OX2R. It reduces spontaneous locomotor activity and orexin-B-induced hyperlocomotion in mice when administered at doses ranging between 10 and 300 mg/kg.
Uses
EMPA is a novel high-affinity, selective antagonist for the OX2 receptor.
storage
Store at -20°C