KL001
- Product Name
- KL001
- CAS No.
- 309928-48-1
- Chemical Name
- KL001
- Synonyms
- KL001(KL-001;KL001, 10 mM in DMSO;KL001(KL-001,KL 001);N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide;N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide;Methanesulfonamide, N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-;Inhibitor,inhibit,stabilizer,KL001,circadian,cryptochrome,ubiquitin,period,gluconeogenesis,CRY
- CBNumber
- CB32695946
- Molecular Formula
- C21H22N2O4S
- Formula Weight
- 398.48
- MOL File
- 309928-48-1.mol
KL001 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
N-Bromosuccinimide Price
- Product number
- SML1032
- Product name
- KL001
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $101.65
- Updated
- 2025/07/31
- Product number
- SML1032
- Product name
- KL001
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $415
- Updated
- 2025/07/31
- Product number
- 233624
- Product name
- Cryptocrome Activator, KL001
- Purity
- The Cryptocrome Activator, KL001 modulates the biological activity of Cryptocrome. This small molecule/inhibitor is primarily used for Biochemicals applications.
- Packaging
- 25 mg
- Price
- $288
- Updated
- 2025/07/31
- Product number
- 13878
- Product name
- KL001
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 13878
- Product name
- KL001
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
KL001 Chemical Properties,Usage,Production
Description
KL-001 (309928-48-1) is a novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes.1?Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure.2?KL-001 induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression3 in mammalian cells.
Uses
KL001 is a small molecule that specifically interacts with cryptochrome (CRY). KL001 prevented ubiquitin-dependent degrdation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes making it a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
Biochem/physiol Actions
KL001 stabilizes cryptochrome (CRY), preventing ubiquitin-dependent degradation. CRY proteins are part of a feedback loop, acting as transcription repressors to inhibit CLOCK-BMAL1 components of the circadian clock. KL001 stabilization of CRY proteins results in lengthening of the circadian period, and also inhibited glucagon-induced gluconeogenesis in primary hepatocytes. Other compounds affecting circadian rhythms include Casein kinase I (CKI) inhibitors such as longdaysin (Sigma Prod. No. SML0127) and synthetic ligands for the nuclear receptors REV-ERB such as SR8278 (Sigma Prod. No. S9576), but KL001 appears to be the first small molecule that specifically acts on CRY proteins.
storage
Store at +4°C
References
[1] TSUYOSHI HIROTA, III Steve A K Peter G Schultz. Identification of Small Molecule Activators of Cryptochrome[J]. Science, 2012, 337 6098. DOI:10.1126/science.1223710
[2] SHANNON NANGLE Ning Z Weiman Xing. Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase[J]. Cell Research, 2013, 23 12: 1417-1419. DOI:10.1038/cr.2013.136
[3] PETER C ST JOHN. Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 5: 2040-2045. DOI:10.1073/pnas.1323618111
KL001 Preparation Products And Raw materials
Raw materials
Preparation Products
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