4-Bromo-1-(bromomethyl)-2-iodobenzene, alpha,4-Dibromo-2-iodotoluene
- Product Name
- 4-Bromo-1-(bromomethyl)-2-iodobenzene, alpha,4-Dibromo-2-iodotoluene
- CAS No.
- 885681-96-9
- Chemical Name
- 4-Bromo-1-(bromomethyl)-2-iodobenzene, alpha,4-Dibromo-2-iodotoluene
- Synonyms
- 4-Bromo-2-Iodobenzyl Bromide;4-Bromo-2-iodobenzylbromide97%;4-Bromo-2-iodobenzyl bromide 97%;4-Bromo-1-(bromomethyl)-2-iodobenzene;Benzene, 4-bromo-1-(bromomethyl)-2-iodo-;4-Bromo-1-(bromomethyl)-2-iodobenzene, alpha,4-Dibromo-2-iodotoluene
- CBNumber
- CB32696695
- Molecular Formula
- C7H5Br2I
- Formula Weight
- 375.83
- MOL File
- 885681-96-9.mol
4-Bromo-1-(bromomethyl)-2-iodobenzene, alpha,4-Dibromo-2-iodotoluene Property
- storage temp.
- 2-8°C(protect from light)
- form
- crystalline powder
- color
- Off white to cream
- InChI
- InChI=1S/C7H5Br2I/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2
- InChIKey
- IHHHQROJDZQCQH-UHFFFAOYSA-N
- SMILES
- C1(CBr)=CC=C(Br)C=C1I
Safety
- HS Code
- 2903998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- OR40663
- Product name
- 4-Bromo-2-iodobenzylbromide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $58
- Updated
- 2021/12/16
- Product number
- 1700-S-03
- Product name
- 4-Bromo-2-iodobenzyl bromide
- Purity
- 97%
- Packaging
- 250mg
- Price
- $64
- Updated
- 2021/12/16
- Product number
- OR40663
- Product name
- 4-Bromo-2-iodobenzylbromide
- Purity
- 97%
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 1700-S-03
- Product name
- 4-Bromo-2-iodobenzyl bromide
- Purity
- 97%
- Packaging
- 1g
- Price
- $176
- Updated
- 2021/12/16
- Product number
- OR40663
- Product name
- 4-Bromo-2-iodobenzylbromide
- Purity
- 97%
- Packaging
- 5g
- Price
- $472
- Updated
- 2021/12/16
4-Bromo-1-(bromomethyl)-2-iodobenzene, alpha,4-Dibromo-2-iodotoluene Chemical Properties,Usage,Production
Synthesis
260558-15-4
885681-96-9
General procedure for the synthesis of 4-bromo-1-(bromomethyl)-2-iodobenzene (15b) from 4-bromo-2-iodo-1-methylbenzene: 4-bromo-2-iodotoluene (3.94 g, 13.3 mmol) was dissolved in 1,2-dichloroethane (19 mL) under nitrogen protection in a 50 mL two-necked round-bottomed flask and stirred at room temperature. Benzoyl peroxide (164 mg, 0.663 mmol) and N-bromosuccinimide (NBS, 2.63 g, 14.6 mmol) were then added sequentially and the reaction mixture was heated to reflux for 5 hours. After completion of the reaction, it was cooled to room temperature, the precipitate was collected by filtration and washed with hexane. The filtrate was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give an orange solid. The solid was washed with cold methanol to give an off-white solid product (3.27 g, 8.75 mmol, 66% yield), which could be used for subsequent reactions without further purification. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 8.01 (d, 1H, J = 2.0 Hz), 7.47 (dd, 1H, J = 8.3, 2.0 Hz), 7.33 (d, 1H, J = 8.3 Hz), 4.54 (s, 2H); High-resolution Mass Spectrometry (HRMS, EI) m/z calculated value C7H5Br2I [M+]: 377.7762, measured value: 377.7759.
References
[1] Patent: TW2016/9616, 2016, A. Location in patent: Paragraph 0162
[2] Journal of Organic Chemistry, 2011, vol. 76, # 7, p. 2227 - 2239
[3] Synthesis, 2011, # 15, p. 2387 - 2391
[4] Patent: WO2011/127383, 2011, A2. Location in patent: Page/Page column 74
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 7, p. 1841 - 1844
4-Bromo-1-(bromomethyl)-2-iodobenzene, alpha,4-Dibromo-2-iodotoluene Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-1-(bromomethyl)-2-iodobenzene, alpha,4-Dibromo-2-iodotoluene Suppliers
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- India
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View Lastest Price from 4-Bromo-1-(bromomethyl)-2-iodobenzene, alpha,4-Dibromo-2-iodotoluene manufacturers
- Product
- 4-Bromo-1-(bromomethyl)-2-iodobenzene, alpha,4-Dibromo-2-iodotoluene 885681-96-9
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08