2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine

Product Name: 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine
CAS No.: 1221171-96-5
Chemical Name: 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine
Synonyms: 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine;Pyridine, 2-chloro-4-iodo-6-(trifluoromethoxy)-
CBNumber: CB32705236
Molecular Formula: C6H2ClF3INO
Formula Weight: 323.44
MOL File: 1221171-96-5.mol

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2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
Appearance: Colorless to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

AK Scientific

Product number: Y1259
Product name: 2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine
Packaging: 100mg
Price: $325
Updated: 2021/12/16

AK Scientific

Product number: Y1259
Product name: 2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine
Packaging: 250mg
Price: $467
Updated: 2021/12/16

Ark Pharm

Product number: AK146247
Product name: 2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine
Purity: 97%
Packaging: 1g
Price: $877
Updated: 2021/12/16

Abosyn

Product number: 61-10836
Product name: 2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine
Purity: 95-98%
Packaging: 1g
Price: $880
Updated: 2021/12/16

Ambeed

Product number: A432709
Product name: 2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine
Purity: 97%
Packaging: 100mg
Price: $197
Updated: 2021/12/16

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2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine Chemical Properties,Usage,Production

Synthesis

1221171-95-4

1221171-96-5

General procedure for the synthesis of 2-chloro-4-iodo-6-trifluoromethoxypyridine from 6-chloro-3-iodo-2-(trifluoromethoxy)pyridine: diisopropylamine (1.4 g, 1.9 mL, 13.6 mmol, 1.1 eq.) was added slowly and dropwise at 0 °C to a butyl lithium (1.56 M hexane solution, 9.0 mL, 13.6 mmol, 1.1 eq.) in a tetrahydrofuran (THF, 20 mL) solution. Subsequently, a solution of 2-chloro-5-iodo-6-trifluoromethoxypyridine (41, 4.0 g, 12.4 mmol, 1 eq.) in THF (10 mL) was added dropwise at -78 °C and the reaction mixture was stirred for 1 hour at 0 °C. Upon completion of the reaction, it was neutralized with 2N hydrochloric acid solution (10 mL), followed by treatment with saturated aqueous sodium bicarbonate solution (30 mL) and extraction with diethyl ether (3 x 20 mL). The organic layers were combined, dried over sodium sulfate and the solvent evaporated. The crude product was purified by vacuum distillation (boiling point 104-107 °C/16 mbar) to afford 2-chloro-4-iodo-6-trifluoromethoxypyridine (42, 3.2 g, 10.9 mmol, 80% yield) as a colorless oil. The structure of the product was determined by 1H NMR (CDCl3, 300 MHz): δ=7.66 (d, J=1.0 Hz, 1H), 7.34 (d, J=1.0 Hz, 1H); 19F NMR (CDCl3, 282 MHz): δ=-57.1; 13C NMR (CDCl3, 75 MHz): δ=155.1, 149.4, 130.7, 120.3, 119.1 (q, J=262 Hz), 108.3 confirmed.

References

[1] Patent: WO2010/40461, 2010, A1. Location in patent: Page/Page column 44
[2] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066

2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine Suppliers

China 34 India 1 United States 3 Global 38

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1221171-96-5