2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Product Name: 2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE
CAS No.: 205444-22-0
Chemical Name: 2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE
Synonyms: 2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2-chloro-4-iodo-6-(trifluoromethyl)-;2-Chloro-4-iodo-6-(trifluoromethyl)pyridine 98%;2-Chloro-4-iodo-6-(trifluoromethyl) pyridine cas
CBNumber: CB42454850
Molecular Formula: C6H2ClF3IN
Formula Weight: 307.44
MOL File: 205444-22-0.mol

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2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE Property

Melting point:: 94-95℃
Boiling point:: 231℃
Density: 2.046
Flash point:: 93℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -4.47±0.10(Predicted)
Appearance: Light brown to yellow Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C368468
Product name: 2-Chloro-4-iodo-6-(trifluoromethyl)pyridine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C368468
Product name: 2-Chloro-4-iodo-6-(trifluoromethyl)pyridine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC87888
Product name: 2-Chloro-4-iodo-6-(trifluoromethyl)pyridine
Packaging: 2g
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC87888
Product name: 2-Chloro-4-iodo-6-(trifluoromethyl)pyridine
Packaging: 5G
Price: $300
Updated: 2021/12/16

AK Scientific

Product number: 0538AB
Product name: 2-Chloro-4-iodo-6-(trifluoromethyl)pyridine
Packaging: 25g
Price: $363
Updated: 2021/12/16

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2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production

Application

2-chloro-4-iodo-6-(trifluoromethyl)pyridine is a useful research chemical.

Synthesis

205240-59-1

205444-22-0

The general procedure for the synthesis of 2-chloro-4-iodo-6-(trifluoromethyl)pyridine from 2-chloro-3-iodo-6-(trifluoromethyl)pyridine was carried out as follows: 2-chloro-3-iodo-6-(trifluoromethyl)pyridine (3.07 g, 10.0 mmol) was dissolved in tetrahydrofuran (35 mL) under nitrogen protection and cooled to -78 °C. Subsequently, a solution of lithium diisopropylammonium (LDA, 5.5 mL, 2 M) was added slowly dropwise via syringe. The reaction mixture was stirred at -78 °C for 1 hour. Upon completion of the reaction, the reaction was quenched with 1 M aqueous hydrochloric acid solution (15 mL) at -78 °C and stirring was continued for 0.5 hr. The reaction mixture was gradually warmed to room temperature and stirred for another 0.5 hr. Subsequently, the mixture was concentrated under reduced pressure to remove the solvent. The aqueous layer was separated and extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (using petroleum ether as eluent) to afford the target product 2-chloro-4-iodo-6-(trifluoromethyl)pyridine (2.5 g, 81% yield) as a white solid. Its NMR hydrogen spectrum (400 MHz, DMSO-d6) data were as follows: δ 8.39 (s, 1H), 8.34 (s, 1H).

References

[1] European Journal of Organic Chemistry, 2004, # 18, p. 3793 - 3798
[2] Patent: WO2016/44792, 2016, A1. Location in patent: Page/Page column 174; 175

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE Suppliers

China 103 Germany 1 India 1 Switzerland 1 United Kingdom 3 United States 5 Global 114

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View Lastest Price from 2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE manufacturers

Career Henan Chemical Co

Product: 2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE 205444-22-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 96%
Supply Ability: 500kg
Release date: 2018-08-20

205444-22-0, 2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINERelated Search:

2-chloro-4-iodo-5-(trifluoromethoxy)pyridine 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine 4-Iodo-2-methylpyridine 2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE 4-Iodo-2-(trifluoromethyl)pyridine

Pyridine, 2-chloro-4-iodo-6-(trifluoromethyl)-

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

2-Chloro-4-iodo-6-(trifluoromethyl)pyridine 98%

2-Chloro-4-iodo-6-(trifluoromethyl) pyridine cas

205444-22-0