2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine
- Product Name
- 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine
- CAS No.
- 1221171-96-5
- Chemical Name
- 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine
- Synonyms
- 2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine;Pyridine, 2-chloro-4-iodo-6-(trifluoromethoxy)-
- CBNumber
- CB32705236
- Molecular Formula
- C6H2ClF3INO
- Formula Weight
- 323.44
- MOL File
- 1221171-96-5.mol
2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Colorless to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- Y1259
- Product name
- 2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine
- Packaging
- 100mg
- Price
- $325
- Updated
- 2021/12/16
- Product number
- Y1259
- Product name
- 2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine
- Packaging
- 250mg
- Price
- $467
- Updated
- 2021/12/16
- Product number
- AK146247
- Product name
- 2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $877
- Updated
- 2021/12/16
- Product number
- 61-10836
- Product name
- 2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $880
- Updated
- 2021/12/16
- Product number
- A432709
- Product name
- 2-Chloro-4-iodo-6-(trifluoromethoxy)pyridine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $197
- Updated
- 2021/12/16
2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine Chemical Properties,Usage,Production
Synthesis
1221171-95-4
1221171-96-5
General procedure for the synthesis of 2-chloro-4-iodo-6-trifluoromethoxypyridine from 6-chloro-3-iodo-2-(trifluoromethoxy)pyridine: diisopropylamine (1.4 g, 1.9 mL, 13.6 mmol, 1.1 eq.) was added slowly and dropwise at 0 °C to a butyl lithium (1.56 M hexane solution, 9.0 mL, 13.6 mmol, 1.1 eq.) in a tetrahydrofuran (THF, 20 mL) solution. Subsequently, a solution of 2-chloro-5-iodo-6-trifluoromethoxypyridine (41, 4.0 g, 12.4 mmol, 1 eq.) in THF (10 mL) was added dropwise at -78 °C and the reaction mixture was stirred for 1 hour at 0 °C. Upon completion of the reaction, it was neutralized with 2N hydrochloric acid solution (10 mL), followed by treatment with saturated aqueous sodium bicarbonate solution (30 mL) and extraction with diethyl ether (3 x 20 mL). The organic layers were combined, dried over sodium sulfate and the solvent evaporated. The crude product was purified by vacuum distillation (boiling point 104-107 °C/16 mbar) to afford 2-chloro-4-iodo-6-trifluoromethoxypyridine (42, 3.2 g, 10.9 mmol, 80% yield) as a colorless oil. The structure of the product was determined by 1H NMR (CDCl3, 300 MHz): δ=7.66 (d, J=1.0 Hz, 1H), 7.34 (d, J=1.0 Hz, 1H); 19F NMR (CDCl3, 282 MHz): δ=-57.1; 13C NMR (CDCl3, 75 MHz): δ=155.1, 149.4, 130.7, 120.3, 119.1 (q, J=262 Hz), 108.3 confirmed.
References
[1] Patent: WO2010/40461, 2010, A1. Location in patent: Page/Page column 44
[2] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066
2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-4-iodo-6-(trifluoroMethoxy)pyridine Suppliers
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