Asthma drugs
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Pranlukast

Asthma drugs
Product Name
Pranlukast
CAS No.
103177-37-3
Chemical Name
Pranlukast
Synonyms
Onon;rs411;Ultair;ono1078;Prenast;Pranlukas;ONO-RS-411;emihydrate;PRANLUKAST;ONO-RS-411-01
CBNumber
CB3271355
Molecular Formula
C27H23N5O4
Formula Weight
481.5
MOL File
103177-37-3.mol
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Pranlukast Property

Melting point:
236-238°C
Density 
1.374±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 25 mg/ml)
pka
4.96±0.10(Predicted)
form 
solid
color 
White
Merck 
14,7710
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference
103177-37-3(CAS DataBase Reference)
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Safety

Hazard Codes 
F,C
Risk Statements 
11-34
Safety Statements 
16-26-36/37/39-45
RTECS 
CV5647500
HS Code 
2934.99.4400
Toxicity
LD50 in male mice (mg/kg): >1000 i.v. (Toda)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
P2115
Product name
Pranlukast
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$39
Updated
2024/03/01
TCI Chemical
Product number
P2115
Product name
Pranlukast
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
10008319
Product name
Pranlukast
Purity
≥98%
Packaging
10mg
Price
$19
Updated
2024/03/01
Cayman Chemical
Product number
10008319
Product name
Pranlukast
Purity
≥98%
Packaging
100mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
10008319
Product name
Pranlukast
Purity
≥98%
Packaging
500mg
Price
$595
Updated
2024/03/01
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Pranlukast Chemical Properties,Usage,Production

Asthma drugs

Pranlukast is a common respiratory drug, it belongs to asthma drugs , it is the cysteinyl leukotrienes (LTs) receptor antagonist and it can bind to LTC4, LTD4, LTE4 receptors selectively to antagonize their effect . Roles and application are similar to zafirlukast. It is clinically used for the prevention of bronchial asthma. Oral 225mg once, 2 times one day, morning and evening after meal. After taking ,there may be gastrointestinal reactions,or there may be nausea, vomiting, abdominal pain, diarrhea or constipation, sometimes , fever, rash, pruritus and liver function abnormalities such as serum aminotransferase or bilirubin increase are visible . Pregnant women should use with caution , the elderly should take appropriate reductions. This product can not alleviate the onset of asthma.
At present, three leukotriene receptor antagonists are used for the following purposes:
1, zafirlukast :it is effective for mild to moderate asthma ,it can cause improvement in dose-dependent lung function, and reduce the amount of β agonists. Absorption of the product is affected by food, it should not be taken together with food. Oral each 20mg, 2 times/d.
2, montelukast: it is valid for intermittent or persistent asthma in adults and children. This product is approved by the FDA for the treatment of children aged 6 to 12. Absorption of the product is not affected by food, it can be taken with food . Oral each 10mg, once/d.
3, pranlukast :it is used for mild to moderate asthma, pranlukast can increase patients maximum expiratory flow,and improve asthma symptoms, it can be used as a daily treatment of chronic asthma. Each oral 450mg, 2 times/d.
The above information is edited by the chemicalbook of Tian Ye.

Description

Pranlukast, a novel chromone derivative, was introduced in Japan for the treatment of bronchial asthma and allergic diseases. Pranlukast is a highly potent, selective and competitive antagonist of peptidoleukotrienes with high affinity for the LTD4 receptor. In patients with bronchial asthma, pranlukast was reported to induce significant improvement in both immediate and late asthmatic response induced by antigen. Pranlukast is also being evaluated clinically for the treatment of perennial allergic rhinitis, pediatric asthma, and cutaneous pruritus in dialysis patients. The therapeutic potential of pranlukast in managing irritable bowel syndrome has been suggested.

Chemical Properties

Off-white solid

Originator

Ono (Japan)

Uses

A potent, selective and orally active CysLT receptor antagonist. Leukotriene antagonist. Used as an antiasthmatic

Uses

antiasthmatic;leukotriene receptor-1 antagonist

Uses

Labeled Pranlukast, intended for use as an internal standard for the quantification of Pranlukast by GC- or LC-mass spectrometry.

Definition

ChEBI: N-[4-oxo-2-(2H-tetrazol-5-yl)-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide is a member of chromones.

brand name

Onon

Biological Activity

Selective cysteinyl leukotriene receptor 1 (CysLT 1 ) antagonist (IC 50 values are ~ 4-7 and 3620 nM for CysLT 1 and CysLT 2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.

References

1) Nakai?et al. (1988),?New Potent Antagonists of Leukotrienes C4 and D4. 1. Synthesis and Structure-Activity Relationships; J. Med. Chem.?31?84 2) Taniguchi?et al.?(1993),?The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects; J. Allergy Clin. Immunol.?92?507 3) Ciana?et al.?(2006),?The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor; EMBO J.?25?4615 4) Hennen?et al. (2013),?Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist; Sci. Signal.?6?ra93

Pranlukast Preparation Products And Raw materials

Raw materials

Preparation Products

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Pranlukast Suppliers

Tianchang Heryi Pharma Co., Ltd.
Tel
+86 (550) 771-1888
Fax
+86 (550) 776-2111
Email
ceo@heryipharma.com
Country
China
ProdList
41
Advantage
50
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
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View Lastest Price from Pranlukast manufacturers

Hebei Ganmiao New material Technology Co., LTD
Product
Pranlukast 103177-37-3
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20ton
Release date
2024-06-06
Hebei Weibang Biotechnology Co., Ltd
Product
Pranlukast 103177-37-3
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2021-11-11
Hebei Mojin Biotechnology Co., Ltd
Product
Pranlukast 103177-37-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-15

103177-37-3, PranlukastRelated Search:


  • PRANLUKAST
  • 4-oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4h-1-benzopyranh
  • benzamide,n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutox
  • emihydrate
  • ONO-RS-411
  • ONO-RS-411-01
  • N-[4-keto-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide
  • N-[4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide
  • N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide
  • n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzam
  • BenzaMide,N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-
  • N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-benzamide
  • 4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran
  • Pranlukast-d4
  • Onon
  • Pranlukast (ONO 1078)
  • ono1078
  • rs411
  • N-{4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide, ONO-1078, ONO-RS-411, Onon,
  • 4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran
  • N-(4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide
  • N-[4-oxo-2-(2H-tetrazol-5-yl)-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide
  • Pranlukast &gt
  • Pranlukast RS
  • Pranlukas
  • EP/GMP/FDA Pranlukast
  • Pranlukast USP/EP/BP
  • Pranlukast (1.0mg/ml in DMSO)
  • Pranlukast (10mM in DMSO)
  • Pranlukast D4Q: What is Pranlukast D4 Q: What is the CAS Number of Pranlukast D4 Q: What is the storage condition of Pranlukast D4 Q: What are the applications of Pranlukast D4
  • Prenast
  • Ultair
  • 103177-37-3
  • C27H23N5O4
  • API
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Antiasthmatic