3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
- Product Name
- 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
- CAS No.
- 136450-06-1
- Chemical Name
- 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
- Synonyms
- 3''-acetyl-2''-hydroxy-4-(4-phenylbutoxy)benzanilide;3''-acetyl-2''-hydroxy-4-(4-phenylbutoxy)benzanilide;N-(3-Acyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide;3-[4-(4-Phenylbutoxy)benzoylamino]-2-hydroxyacetophenone;N-(3-acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide;3’-[4-(4-Phenylbutoxy)benzoylamino]-2’-hydroxyacetophenone;3-[4-(4-phenyl-1-butoxy)benzoyl]amino-2-hydroxyacetophenone;Benzamide, N-(3-acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)-;N-(3-acetyl-2-hydroxyphe ny\-a-@- phenylbutoxy)benzamide 136450-06-1;3'-[4-(4-Phenylbutoxy)benzoylamino]-2'-hydroxyacetophenone (Pranlukast)
- CBNumber
- CB81476202
- Molecular Formula
- C25H25NO4
- Formula Weight
- 403.47
- MOL File
- 136450-06-1.mol
3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE Property
- Boiling point:
- 528.0±50.0 °C(Predicted)
- Density
- 1.213±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.50±0.40(Predicted)
- Appearance
- Light yellow to yellow Powder
- InChI
- InChI=1S/C25H25NO4/c1-18(27)22-11-7-12-23(24(22)28)26-25(29)20-13-15-21(16-14-20)30-17-6-5-10-19-8-3-2-4-9-19/h2-4,7-9,11-16,28H,5-6,10,17H2,1H3,(H,26,29)
- InChIKey
- NTUBQTVFDLDHRH-UHFFFAOYSA-N
- SMILES
- C(NC1=CC=CC(C(C)=O)=C1O)(=O)C1=CC=C(OCCCCC2=CC=CC=C2)C=C1
N-Bromosuccinimide Price
- Product number
- N497163
- Product name
- N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 6475AA
- Product name
- N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
- Packaging
- 5g
- Price
- $158
- Updated
- 2021/12/16
- Product number
- 095854
- Product name
- N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- CHM0384920
- Product name
- N-(3-ACETYL-2-HYDROXYPHENYL)-4-(4-PHENYLBUTOXY)BENZAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.48
- Updated
- 2021/12/16
- Product number
- CD12148493
- Product name
- N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
- Purity
- 95+%
- Packaging
- 100g
- Price
- $653
- Updated
- 2021/12/16
3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE Chemical Properties,Usage,Production
Synthesis
30131-16-9
70977-72-9
136450-06-1
The general procedure for the synthesis of 3-[4-(4-phenylbutoxy)benzoylamino]-2-hydroxyacetophenone from 4-phenylbutoxybenzoic acid and 3-amino-2-hydroxyacetophenone was as follows: first, 270 g of 4-(phenylbutoxy)benzoic acid was mixed with 270 g of thionyl chloride, and the reaction was carried out for 3 hours at 50 °C. Upon completion of the reaction, the unreacted thionyl chloride was recovered by distillation under reduced pressure. Subsequently, the reaction product was dissolved in 270 g of dichloromethane under nitrogen protection and cooled to room temperature. Another 151 g of 3-amino-2-hydroxyacetophenone was dissolved in 200 g of dichloromethane, 160 g of pyridine was added, and then a dichloromethane solution of 4-(phenylbutoxy)benzoyl chloride prepared as described above was slowly added dropwise under the condition of an ice bath, and the reaction temperature was controlled to be no more than 10 ℃. After the dropwise addition was completed, the reaction was continued at 10°C for 2 hours. At the end of the reaction, the pH of the reaction mixture was adjusted to 2-3 with dilute hydrochloric acid, the organic layer was separated, washed to neutrality with dichloromethane, dried over anhydrous sodium sulfate, filtered and concentrated to give a reddish brown solid. Finally, it was recrystallized by a solvent mixture of petroleum ether and ethyl acetate (1:1, v/v) to give 334 g of the target product in 84% yield.
References
[1] Patent: CN106588897, 2017, A. Location in patent: Paragraph 0019
3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE manufacturers
- Product
- 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE 136450-06-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000
- Release date
- 2025-05-12
- Product
- 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE 136450-06-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11