ChemicalBook > CAS DataBase List > 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE

3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE

Product Name: 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
CAS No.: 136450-06-1
Chemical Name: 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE
Synonyms: 3''-acetyl-2''-hydroxy-4-(4-phenylbutoxy)benzanilide;3''-acetyl-2''-hydroxy-4-(4-phenylbutoxy)benzanilide;N-(3-Acyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide;3-[4-(4-Phenylbutoxy)benzoylamino]-2-hydroxyacetophenone;N-(3-acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide;3’-[4-(4-Phenylbutoxy)benzoylamino]-2’-hydroxyacetophenone;3-[4-(4-phenyl-1-butoxy)benzoyl]amino-2-hydroxyacetophenone;Benzamide, N-(3-acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)-;N-(3-acetyl-2-hydroxyphe ny\-a-@- phenylbutoxy)benzamide 136450-06-1;3'-[4-(4-Phenylbutoxy)benzoylamino]-2'-hydroxyacetophenone (Pranlukast)
CBNumber: CB81476202
Molecular Formula: C25H25NO4
Formula Weight: 403.47
MOL File: 136450-06-1.mol

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3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE Property

Boiling point:: 528.0±50.0 °C(Predicted)
Density: 1.213±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 9.50±0.40(Predicted)
Appearance: Light yellow to yellow Powder
InChI: InChI=1S/C25H25NO4/c1-18(27)22-11-7-12-23(24(22)28)26-25(29)20-13-15-21(16-14-20)30-17-6-5-10-19-8-3-2-4-9-19/h2-4,7-9,11-16,28H,5-6,10,17H2,1H3,(H,26,29)
InChIKey: NTUBQTVFDLDHRH-UHFFFAOYSA-N
SMILES: C(NC1=CC=CC(C(C)=O)=C1O)(=O)C1=CC=C(OCCCCC2=CC=CC=C2)C=C1

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Safety

Risk Statements: 53
Safety Statements: 61

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: N497163
Product name: N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
Packaging: 500mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: 6475AA
Product name: N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
Packaging: 5g
Price: $158
Updated: 2021/12/16

Matrix Scientific

Product number: 095854
Product name: N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
Purity: 95+%
Packaging: 250mg
Price: $288
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0384920
Product name: N-(3-ACETYL-2-HYDROXYPHENYL)-4-(4-PHENYLBUTOXY)BENZAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $499.48
Updated: 2021/12/16

Crysdot

Product number: CD12148493
Product name: N-(3-Acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide
Purity: 95+%
Packaging: 25g
Price: $262
Updated: 2021/12/16

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3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE Chemical Properties,Usage,Production

Synthesis

30131-16-9

70977-72-9

136450-06-1

The general procedure for the synthesis of 3-[4-(4-phenylbutoxy)benzoylamino]-2-hydroxyacetophenone from 4-phenylbutoxybenzoic acid and 3-amino-2-hydroxyacetophenone was as follows: first, 270 g of 4-(phenylbutoxy)benzoic acid was mixed with 270 g of thionyl chloride, and the reaction was carried out for 3 hours at 50 °C. Upon completion of the reaction, the unreacted thionyl chloride was recovered by distillation under reduced pressure. Subsequently, the reaction product was dissolved in 270 g of dichloromethane under nitrogen protection and cooled to room temperature. Another 151 g of 3-amino-2-hydroxyacetophenone was dissolved in 200 g of dichloromethane, 160 g of pyridine was added, and then a dichloromethane solution of 4-(phenylbutoxy)benzoyl chloride prepared as described above was slowly added dropwise under the condition of an ice bath, and the reaction temperature was controlled to be no more than 10 ℃. After the dropwise addition was completed, the reaction was continued at 10°C for 2 hours. At the end of the reaction, the pH of the reaction mixture was adjusted to 2-3 with dilute hydrochloric acid, the organic layer was separated, washed to neutrality with dichloromethane, dried over anhydrous sodium sulfate, filtered and concentrated to give a reddish brown solid. Finally, it was recrystallized by a solvent mixture of petroleum ether and ethyl acetate (1:1, v/v) to give 334 g of the target product in 84% yield.

References

[1] Patent: CN106588897, 2017, A. Location in patent: Paragraph 0019

3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE 136450-06-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000
Release date: 2025-05-12

Career Henan Chemical Co

Product: 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE 136450-06-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

136450-06-1, 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDERelated Search:

BENZANILIDE 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran Pranlukast 8-[[P-(4-PHENYLBUTOXY)BENZOYL]AMINO]-2-METHOXYCARBONYL-4-OXO-4H-1-BENZOPYRAN

N-(3-acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide

3-[4-(4-Phenylbutoxy)benzoylamino]-2-hydroxyacetophenone

3-[4-(4-phenyl-1-butoxy)benzoyl]amino-2-hydroxyacetophenone

3'-[4-(4-Phenylbutoxy)benzoylamino]-2'-hydroxyacetophenone (Pranlukast)

Benzamide, N-(3-acetyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)-

N-(3-acetyl-2-hydroxyphe ny\-a-@- phenylbutoxy)benzamide 136450-06-1

3''-acetyl-2''-hydroxy-4-(4-phenylbutoxy)benzanilide

3’-[4-(4-Phenylbutoxy)benzoylamino]-2’-hydroxyacetophenone

N-(3-Acyl-2-hydroxyphenyl)-4-(4-phenylbutoxy)benzamide

3''-acetyl-2''-hydroxy-4-(4-phenylbutoxy)benzanilide

136450-06-1