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FADROZOLE

Product Name
FADROZOLE
CAS No.
102676-47-1
Chemical Name
FADROZOLE
Synonyms
Afema;FAD286;CS-2710;FAD 286);CGS-16949;FADROZOLE;CGS-169494;FADROZOLE USP/EP/BP;Fadrozole (CGS 16949A;Fadrozole, 10 mM in DMSO
CBNumber
CB3271421
Molecular Formula
C14H13N3
Formula Weight
223.27
MOL File
102676-47-1.mol
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FADROZOLE Property

Melting point:
0°C
Boiling point:
0°C
Density 
1.20
Flash point:
0°C
storage temp. 
2-8°C
solubility 
DMSO : ≥ 100 mg/mL (447.89 mM)
form 
Solid
pka
7.16±0.40(Predicted)
color 
White to off-white
EPA Substance Registry System
Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)- (102676-47-1)
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Safety

Risk Statements 
20/21/22
Safety Statements 
22-24/25
RIDADR 
3439
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0002673
Product name
FADROZOLE
Purity
95.00%
Packaging
1G
Price
$975.45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002673
Product name
FADROZOLE
Purity
95.00%
Packaging
5G
Price
$1855.51
Updated
2021/12/16
Arctom
Product number
AS554511
Product name
4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
Purity
≥95%
Packaging
1g
Price
$1339
Updated
2021/12/16
Arctom
Product number
AS554511
Product name
4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
Purity
≥95%
Packaging
5mg
Price
$39
Updated
2021/12/16
Ambeed
Product number
A428094
Product name
4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
Purity
95+%
Packaging
5mg
Price
$71
Updated
2021/12/16
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FADROZOLE Chemical Properties,Usage,Production

Chemical Properties

Melting point 117-118°C.
Fadrozole Hydrochloride: C14H13N3·HCl. [102676-96-0]. Crystallized from isopropyl alcohol, melting point 231-233°C. Soluble in water.

Uses

Antineoplastic

Definition

ChEBI: 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile is an imidazopyridine.

in vivo

Fadrozole hydrochloride is able to inhibit the aromatase-mediated androstenedione-induced uterine hypertrophy in immature female rats with an ED50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED50 of 30 mg/kg when given orally[1]. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars dta mas in female rats, and reduces the of spontaneous hcu ar tumours in male and female rats[2]. Administration of fadrozole in male and female mice suppresses the production of 17b-estradiol, accompanied with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole treatment returns these levels to baseline values[3].

IC 50

Aromatase

FADROZOLE Preparation Products And Raw materials

Raw materials

Concentrated sulfuric acid

Preparation Products

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FADROZOLE Suppliers

China 68 Europe 2 Germany 1 United Kingdom 1 United States 16 Global 88
MedChemexpress LLC
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View Lastest Price from FADROZOLE manufacturers

Dideu Industries Group Limited
Product
FADROZOLE 102676-47-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-02
Shaanxi Dideu Medichem Co. Ltd
Product
Fadrozole 102676-47-1
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

102676-47-1, FADROZOLERelated Search:

Exemestane FADROZOLE HYDROCHLORIDE FADROZOLE 4-(1H-IMIDAZOL-1-YLMETHYL)BENZONITRILE

  • FADROZOLE
  • 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridine-5-yl)benzonitrile
  • 4-[(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin)-5-yl]benzonitrile
  • 4-[[5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin]-5-yl]benzonitrile
  • 5,6,7,8-Tetrahydro-5-(4-cyanophenyl)imidazo[1,5-a]pyridine
  • CGS-16949
  • Fadrozole Hydrochloride Hydrate
  • Afema
  • CGS-169494
  • 4-(5，6，7，8-Tetrahydroimidazo[1，5-α]pyridin-5-y1)benzonitrile
  • FAD 286)
  • FAD286
  • Fadrozole (CGS 16949A
  • CS-2710
  • Benzonitrile,4-(5,6,7,8-tetrahydroiMidazo[1,5-a]pyridin-5-yl)-
  • 4-{5H,6H,7H,8H-iMidazo[1,5-a]pyridin-5-yl}benzonitrile
  • FADROZOLE USP/EP/BP
  • (Rac)-FAD286,inhibit,Fadrozole,CGS 16949A,Inhibitor,Aromatase
  • Fadrozole, 10 mM in DMSO
  • 102676-47-1