ChemicalBook > CAS DataBase List > 2-Bromo-3'-chloropropiophenone

2-Bromo-3'-chloropropiophenone

Product Name
2-Bromo-3'-chloropropiophenone
CAS No.
34911-51-8
Chemical Name
2-Bromo-3'-chloropropiophenone
Synonyms
2-BROMO-1-(3-CHLOROPHENYL)PROPAN-1-ONE;DK749;2B3CP;2-Bromo Bupropion;Bupropion Impurity 5;Bupropion Impurity 42;Bupropion impurity M1-9;Bromo Chloropropiophenone;Bupropion 2-BroMo IMpurity;Bupropion Related Compound G
CBNumber
CB3271779
Molecular Formula
C9H8BrClO
Formula Weight
247.52
MOL File
34911-51-8.mol
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2-Bromo-3'-chloropropiophenone Property

Boiling point:
148-148.5 °C(Press: 9 Torr)
Density 
1.532
refractive index 
1.5770
storage temp. 
Refrigerator, Under Inert Atmosphere
solubility 
Soluble in acetonitrile, chloroform, dichloromethane and ethyl acetate.
form 
Liquid
color 
Colorless to pale yellow
InChI
InChI=1S/C9H8BrClO/c1-6(10)9(12)7-3-2-4-8(11)5-7/h2-6H,1H3
InChIKey
OFNMQTRHMBQQEA-UHFFFAOYSA-N
SMILES
C(C1=CC=CC(Cl)=C1)(=O)C(Br)C
CAS DataBase Reference
34911-51-8(CAS DataBase Reference)
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Safety

HazardClass 
IRRITANT
HS Code 
2914790000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H64999
Product name
2-Bromo-3'-chloropropiophenone, 98%
Packaging
1g
Price
$29.65
Updated
2024/03/01
Alfa Aesar
Product number
H64999
Product name
2-Bromo-3'-chloropropiophenone, 98%
Packaging
5g
Price
$114.65
Updated
2024/03/01
TRC
Product number
C365035
Product name
3’-Chloro-2-bromopropiophenone
Packaging
1g
Price
$520
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20015
Product name
3'-Chloro-2-bromopropiophenone
Packaging
1g
Price
$600.6
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0045851
Product name
BUPROPION RELATED COMPOUND G
Purity
95.00%
Packaging
5MG
Price
$620
Updated
2021/12/16
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2-Bromo-3'-chloropropiophenone Chemical Properties,Usage,Production

Chemical Properties

Yellow Oil

Uses

It used as an important intermediate for raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Definition

2-Bromo-3'-chloropropiophenone (BCP), a yellow oil, is an intermediate used in the synthesis of bupropion and is also found as an impurity of bupropion hydrochloride. Bupropion is a second-generation antidepressant that was originally approved by the United States Food and Drug Administration (FDA) in 1985. It is a norepinephrine and dopamine transporter inhibitor and an antagonist at neuronal nicotinic acetylcholine receptors. Bupropion is also approved for smoking cessation[1].

Safety

The current United States Pharmacopeia (USP) specification is for no more than 0.1% BCP in the bupropion hydrochloride monograph. The Material Safety Data Sheet from a manufacturer indicates that BCP is irritating to the eyes, respiratory system, and skin. 2-Bromo-3'-chloropropiophenone was mutagenic with S9 metabolic activation, increasing the mutant frequencies in a concentration-dependent manner, up to 22- and 145-fold induction over the controls in Salmonella strains TA100 and TA1535, respectively. BCP was also positive in the in vitro micronucleus assay, resulting in up to 3.3- and 5.1-fold increase of micronucleus frequency for treatments in the absence and presence of S9, respectively; and 9.9- and 7.4-fold increase of aneuploidies without and with S9, respectively. The addition of N-acetyl-l-cysteine, an antioxidant, reduced the genotoxicity of BCP in both assays. Further studies showed that BCP treatment resulted in induction of reactive oxygen species (ROS) in the TK6 cells. The results suggest that BCP is mutagenic, clastogenic, and aneugenic, and that these activities are mediated via generation of reactive metabolites[1].

References

[1] Meng, Fanxue , et al. "Genotoxicity of 2-bromo-3′-chloropropiophenone." Toxicology & Applied Pharmacology 270.2(2013):158-163.

2-Bromo-3'-chloropropiophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-3'-chloropropiophenone manufacturers

Dorne Chemical Technology co. LTD
Product
2-Bromo-3'-chloropropiophenone 34911-51-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000kg
Release date
2024-03-26
Nanjing Deda New Material Technology Co., Ltd
Product
2-Bromo-3'-chloropropiophenone 34911-51-8
Price
US $15.00-10.00/kg
Min. Order
1kg
Purity
99.5
Supply Ability
10 ton per month
Release date
2024-03-12
Nanjing Deda New Material Technology Co., Ltd
Product
2-Bromo-3'-chloropropiophenone 34911-51-8
Price
US $15.00-10.00/kg
Min. Order
1kg
Purity
99.5
Supply Ability
10 ton per month
Release date
2024-03-12

34911-51-8, 2-Bromo-3'-chloropropiophenoneRelated Search:

Propiophenone Chlorphenamine maleate BROMOACETONE Calcium pyruvate 3'-Chloropropiophenone Pyruvic acid Acetylacetone 3-Chloropropiophenone Propane 1-(3-Chlorophenyl)-1,2-propanedione Bupropion Impurity 1 2-(tert-Butylamino)-3',5'-dichloropropiophenone Hydrochloride Bupropion IMpurity ((3R,5RS,6RS)-6-(3-Chlorophenyl)-6-Hydroxy-5-Methyl-3-ThioMorpholine Carboxylic Acid) (3S,5S,6S)-Bupropion Impurity 3-Chlorobenzoic acid Bupropion Impurity 6 Bupropion Impurity 10 (3S,5R,6R)-Bupropion Impurity

  • 2-BROMO-1-(3-CHLOROPHENYL)-1-PROPANONE
  • 2-BROMO-1-(3-CHLOROPHENYL)PROPAN-1-ONE
  • 2-BROMO-3'-CHLOROPROPIOPHENONE
  • 3'-CHLORO-2-BROMOPROPIOPHENONE
  • 3'-Chloro-α-bromopropiophenone
  • 1-Propanone,2-broMo-1-(3-chlorophenyl)-
  • α-BroMo-3-chloropropiophenone
  • Bupropion 2-BroMo IMpurity
  • Bupropion Impurity 5
  • Bupropion impurity M1-9
  • 2-Bromo-3'-chloropropiophenone, 2-Bromo-1-(3-chlorophenyl)-1-propanone
  • 2-Bromo-1-(3-chlorophenyl)propan-1-
  • 2-Bromo Bupropion
  • Bupropion Impurity 42
  • 2-Bromo-3'-chloropropiophenone,98%
  • 2-Bromo Bupropion ImpurityQ: What is 2-Bromo Bupropion Impurity Q: What is the CAS Number of 2-Bromo Bupropion Impurity Q: What is the storage condition of 2-Bromo Bupropion Impurity Q: What are the applications of 2-Bromo Bupropion Impurity
  • Bupropion Related Compound G
  • Bupropion USP Related Compound G
  • DK749
  • Bromo Chloropropiophenone
  • 2-Bromo-3’-Chloropropiophenone (Intermediate of Bupropion )
  • Bupropion Related Compound G (50 mg) (2-Bromo-1-(3-chlorophenyl)propan-1-one)
  • 2B3CP
  • 2-Bromo-3'-chloropropiophenone
  • 2'Bromo-3'Chloropropiophenone
  • 34911-51-8
  • 34911-54-8
  • C9H9BrClC
  • Aromatics