Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl-

Product Name: Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl-
CAS No.: 212391-58-7
Chemical Name: Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl-
Synonyms: PP58;PP58,PP-58;PP58, 10 mM in DMSO;2-((4-(2-Aminoethoxy)phenyl)amino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl-
CBNumber: CB32729270
Molecular Formula: C22H19Cl2N5O2
Formula Weight: 456.32
MOL File: 212391-58-7.mol

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Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl- Property

Boiling point:: 663.7±65.0 °C(Predicted)
Density: 1.426±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 8.57±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5943
Product name: PP58
Purity: 99.48%
Packaging: 1mg
Price: $168
Updated: 2021/12/16

Iris Biotech GmbH

Product number: LS-4090
Product name: PP58
Packaging: 1mg
Price: $270
Updated: 2021/12/16

ChemScene

Product number: CS-5943
Product name: PP58
Purity: 99.48%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-5943
Product name: PP58
Purity: 99.48%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-5943
Product name: PP58
Purity: 99.48%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

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Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl- Chemical Properties,Usage,Production

Uses

PP58 is a pyrido[2,3-d]pyrimidine-based compound that inhibits PDGFR, FGFR and Src family activities with nanomolar IC50 values.

in vivo

PP58 can exhibit some degree of selectivity at low nanomolar concentrations in vivo^[1].

IC 50

PDGFR

References

[1] Wissing J, et al. Chemical Proteomic Analysis Reveals Alternative Modes of Action for Pyrido[2,3-d]pyrimidine Kinase Inhibitors. Mol Cell Proteomics. 2004 Dec;3(12):1181-93. DOI:10.1074/mcp.M400124-MCP200
[2] Blencke S, et al. Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors. Chem Biol. 2004 May;11(5):691-701. DOI:10.1016/j.chembiol.2004.02.029

Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl- Suppliers

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212391-58-7, Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl-Related Search:

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Pyrido[2,3-d]pyrimidin-7(8H)-one,2-[[4-(2-aminoethoxy)phenyl]amino]-6-(2,6-dichlorophenyl)-8-methyl-

PP58

2-((4-(2-Aminoethoxy)phenyl)amino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

PP58,PP-58

PP58, 10 mM in DMSO

212391-58-7