MPI-0479605

Product Name: MPI-0479605
CAS No.: 1246529-32-7
Chemical Name: MPI-0479605
Synonyms: CS-1459;MPI-0479605;MPI0479605 HCl;MPI-0479605 USP/EP/BP;MPI-0479605;MPI 0479605;MPI0479605;N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine;N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine;9H-?Purine-?2,?6-?diamine, N6-?cyclohexyl-?N2-?[2-?methyl-?4-?(4-?morpholinyl)?phenyl]?-
CBNumber: CB32731101
Molecular Formula: C22H29N7O
Formula Weight: 407.51
MOL File: 1246529-32-7.mol

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MPI-0479605 Property

Boiling point:: 745.8±70.0 °C(Predicted)
Density: 1.318±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO
form: A crystalline solid
pka: 10.52±0.10(Predicted)
color: White to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22136
Product name: MPI-0479605
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 22136
Product name: MPI-0479605
Purity: ≥98%
Packaging: 5mg
Price: $233
Updated: 2024/03/01

Cayman Chemical

Product number: 22136
Product name: MPI-0479605
Purity: ≥98%
Packaging: 10mg
Price: $437
Updated: 2024/03/01

Cayman Chemical

Product number: 22136
Product name: MPI-0479605
Purity: ≥98%
Packaging: 25mg
Price: $957
Updated: 2024/03/01

AK Scientific

Product number: 2574AH
Product name: N6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine
Packaging: 1g
Price: $1246
Updated: 2021/12/16

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MPI-0479605 Chemical Properties,Usage,Production

Description

MPI-0479605 is a potent and ATP-competitive inhibitor of the mitotic kinase MPS1 (IC₅₀ = 1.8 nM). It is selective for MPS1 over a panel of 79 kinases at a concentration of 500 nM. MPI-0479605 induces time-dependent degradation of cyclin B and securin and decreases phosphorylation of BUBR1 resulting in failed cytokinesis in HeLa cells arrested by nocodazole . It also causes misalignment of chromosomes at the anaphase plate and aneuploidy in A549 cells and slows cell cycle progression of HCT116 and COLO 205 cells irrespective of p53 activity. MPI-0479605 (30-150 mg/kg) reduces tumor volume in an HCT116 mouse colon cancer xenograft model in a dose-dependent manner.

References

[1] tardif k d, rogers a, cassiano j, et al. characterization of the cellular and antitumor effects of mpi-0479605, a small-molecule inhibitor of the mitotic kinase mps1. molecular cancer therapeutics, 2011, 10(12): 2267-2275.

MPI-0479605 Preparation Products And Raw materials

Raw materials

Preparation Products

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MPI-0479605 Suppliers

China 77 India 1 United Kingdom 1 United States 11 Global 90

Shanghai Boyle Chemical Co., Ltd.

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Dalian Meilun Biotech Co., Ltd.

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Email: sales@meilune.com
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Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
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AdooQ Bioscience CHINA

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Shanghai Lollane Biological Technology Co.,Ltd.

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Fax: +86-21-52996696
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Shanghaizehan biopharma technology co., Ltd.

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Fax: 021-61350662
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D&C Chemicals

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Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
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View Lastest Price from MPI-0479605 manufacturers

Career Henan Chemical Co

Product: MPI-0479605 1246529-32-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-25

1246529-32-7, MPI-0479605Related Search:

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MPI-0479605

N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine

MPI0479605 HCl

N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine

MPI-0479605;MPI 0479605;MPI0479605

9H-?Purine-?2,?6-?diamine, N6-?cyclohexyl-?N2-?[2-?methyl-?4-?(4-?morpholinyl)?phenyl]?-

CS-1459

MPI-0479605 USP/EP/BP

1246529-32-7

C22H29N7O

Inhibitors