Voruciclib

Product Name: Voruciclib
CAS No.: 1000023-04-0
Chemical Name: Voruciclib
Synonyms: CS-2788;P1446A05;P1446A 05;P1446A-05;Voruciclib;UNII-W66XP666AM;Voruciclib (P1446A-05);Voruciclib, 10 mM in DMSO;P1446A05; P1446A-05; P1446A 05; VORUCICLIB;2-(2-chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one
CBNumber: CB32731161
Molecular Formula: C22H19ClF3NO5
Formula Weight: 469.84
MOL File: 1000023-04-0.mol

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Voruciclib Property

Boiling point:: 587.6±50.0 °C(Predicted)
Density: 1.493±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A crystalline solid
pka: 6.36±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29085
Product name: Voruciclib
Packaging: 1mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 29085
Product name: Voruciclib
Packaging: 10mg
Price: $530
Updated: 2024/03/01

Cayman Chemical

Product number: 29085
Product name: Voruciclib
Packaging: 5mg
Price: $289
Updated: 2024/03/01

ChemScene

Product number: CS-0011273
Product name: Voruciclib
Purity: 99.52%
Packaging: 1mg
Price: $280
Updated: 2021/12/16

ChemScene

Product number: CS-0011273
Product name: Voruciclib
Purity: 99.52%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

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Voruciclib Chemical Properties,Usage,Production

Uses

Voruciclib is a cyclin-dependent kinase (CDK) inhibitor. It is a derivative of Flavone (F371050) and can be used for treatment of proliferative disorders such as cancer.

in vivo

Combination of Voruciclib hydrochloride (200 mpk; Oral gavage) and Venetoclax (10 mpk, 1 mpk, 50 mpk, 25 mpk in U2932, RIVA, SU-DHL-4 and NU-DHL-1, respectively) leads to enhance tumor growth inhibition compared to either drug alone in U2932, RIVA, SU-DHL-4 (six days per week for 4 weeks), and NU-DHL-1 models (five days per week for 3 weeks) of DLBCL^[1].

Animal Model:	ABC subtypes (U2932, RIVA, OCI-LY10), GCB subtypes (SU-DHL-4, NU-DHL-1) xenografted in Female NOD.CB17-Prkdcscid/NCrHsd mice
Dosage:	200 mpk
Administration:	Oral gavage; U2932, RIVA, SU-DHL-4 (six days per week for 4 weeks), OCI-LY10 (six days per week for 2 weeks), NU-DHL-1 (five days per week for 3 weeks)
Result:	Enhanced tumor growth inhibition in U2932, RIVA, SU-DHL-4 and NU-DHL-1 models except in OCI-LY10 model.

IC 50

CDK9/cyc T2: 0.626 nM (Ki); CDK9/CycT1: 1.68 nM (Ki); CDK6/cycD1: 2.92 nM (Ki); CDK4/Cyc D1: 3.96 nM (Ki); CDK1/cycB: 5.4 nM (Ki); CDK1/cyc A: 9.1 nM (Ki)

Voruciclib Preparation Products And Raw materials

Raw materials

Preparation Products

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Voruciclib Suppliers

China 61 United States 7 Global 68

Shanghai Boyle Chemical Co., Ltd.

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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
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Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghai Chaolan Chemical Technology Center

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Chuzhou KeMail Chemical Technology Co., Ltd

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Chemleader Biomedical Co., Limited.

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Twochem Co.Ltd.

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1000023-04-0, VoruciclibRelated Search:

Voruciclib

2-[2-Chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one

UNII-W66XP666AM

2-(2-chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one

CS-2788

P1446A 05

P1446A05

P1446A-05

P1446A05; P1446A-05; P1446A 05; VORUCICLIB

4H-1-Benzopyran-4-one, 2-[2-chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-

Voruciclib (P1446A-05)

Cyclin dependent kinase,CDK,B-cell,multiple,inhibit,diffuse,clinical,models,DLBCL,MCL-1,large,CDK9,Inhibitor,Voruciclib,stage,orally,lymphoma

Voruciclib, 10 mM in DMSO

1000023-04-0

C22H19ClF3NO5