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SBE13

Product Name
SBE13
CAS No.
775294-82-1
Chemical Name
SBE13
Synonyms
SBE13;[4-(6-Chloro-pyridin-3-ylmethoxy)-3-methoxy-benzyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine;Benzeneethanamine, N-[[4-[(6-chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-
CBNumber
CB32735538
Molecular Formula
C24H27ClN2O4
Formula Weight
442.94
MOL File
775294-82-1.mol
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SBE13 Property

Boiling point:
582.8±45.0 °C(Predicted)
Density 
1.196±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
8.67±0.19(Predicted)
form 
solid
color 
beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
528281
Product name
Polo-like Kinase Inhibitor IV, SBE13 - CAS 775294-82-1 - Calbiochem
Packaging
10MG
Price
$133
Updated
2025/07/31
Crysdot
Product number
CD31000818
Product name
SBE13
Purity
98+%
Packaging
50mg
Price
$208
Updated
2021/12/16
Crysdot
Product number
CD31000818
Product name
SBE13
Purity
98+%
Packaging
10mg
Price
$54
Updated
2021/12/16
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SBE13 Chemical Properties,Usage,Production

Uses

SBE13 is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 poorly inhibits Plk2 (IC50>66?μM) or Plk3 (IC50=875?nM).

IC 50

PLK1: 200 pM (IC50); PLK3: 875 nM (IC50)

References

[1] Keppner S, et al. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem. 2009 Nov;4(11):1806-9. DOI:10.1002/cmdc.200900338
[2] Keppner S, et al. Fate of primary cells at the G?/S boundary after polo-like kinase 1 inhibition by SBE13. Cell Cycle. 2011 Feb 15;10(4):708-20. Epub 2011 Feb 15. DOI:10.4161/cc.10.4.14898
[3] Keppner S, et al. Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle. 2010 Feb 15;9(4):761-73. Epub 2010 Feb 16. DOI:10.4161/cc.9.4.10644

SBE13 Preparation Products And Raw materials

Raw materials

Preparation Products

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SBE13 Suppliers

China 13 United States 4 Global 17
MedChemexpress LLC
Tel
021-58955995
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609-228-5909
Email
sales@medchemexpress.cn
Country
United States
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4861
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Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
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China
ProdList
12475
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Musechem
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+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3276
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58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
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58
Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
Country
China
ProdList
24731
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 18100677375
Email
sales@szzxbio.com
Country
China
ProdList
2993
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58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
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Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
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6215
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775294-82-1, SBE13Related Search:

SBE 13 hydrochloride

  • SBE13
  • [4-(6-Chloro-pyridin-3-ylmethoxy)-3-methoxy-benzyl]-[2-(3,4-dimethoxy-phenyl)-ethyl]-amine
  • Benzeneethanamine, N-[[4-[(6-chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-
  • 775294-82-1