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SBE 13 hydrochloride

Product Name
SBE 13 hydrochloride
CAS No.
1052532-15-6
Chemical Name
SBE 13 hydrochloride
Synonyms
CS-1632;SBE-13 HCl;SBE13 HydrochL;SBE 13 hydrochloride;SBE 13 hydrochloride USP/EP/BP;SBE 13 hydrochloride >=98% (HPLC);N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine;N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine;N-(4-((6-chloropyridin-3-yl)Methoxy)-3-Methoxybenzyl)-2-(3,4-diMethoxyphenyl)ethanaMine hydrochloride;N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride
CBNumber
CB82552606
Molecular Formula
C24H28Cl2N2O4
Formula Weight
479.4
MOL File
1052532-15-6.mol
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SBE 13 hydrochloride Property

storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: ≥17mg/mL
form 
powder
color 
white to tan
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0012
Product name
SBE 13 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2022/05/15
Cayman Chemical
Product number
21241
Product name
SBE 13 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
21241
Product name
SBE 13 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$111
Updated
2024/03/01
Cayman Chemical
Product number
21241
Product name
SBE 13 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$232
Updated
2024/03/01
Cayman Chemical
Product number
21241
Product name
SBE 13 (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$421
Updated
2024/03/01
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SBE 13 hydrochloride Chemical Properties,Usage,Production

Description

SBE 13 is a potent inhibitor of polo-like kinase 1 (Plk1) (IC50 = 0.2 nM) that targets the inactive conformation of the enzyme . It exhibits no activity against aurora A kinase and less effectively inhibits Plk2 (IC50 > 66 μM) and Plk3 (IC50 = 875 nM). SBE 13 induces cell cycle arrest, reduces cell proliferation (EC50 = 5-60 μM), and induces apoptosis in a broad range of human cancer cell lines.

Uses

SBE13 Hydrochloride is a selective inhibitor of PLK1.

in vitro

to determine its ability to induce cell death in cancer cells, we applied kinase assays, western blot analyses, facs can analyses, caspase assays and immunofluorescence studies. we detected decreased cell proliferation, delayed progression through the cell cycle in lower sbe13 concentrations, a g2/m arrest using higher sbe13 concentrations followed by apoptosis, and abnormal mitotic figures. notably, sbe13 did not influence activity of other kinases (plk2, plk3, aurora a), indicating the selectivity of this type ii plk1 inhibitor [1].

SBE 13 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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SBE 13 hydrochloride Suppliers

China 61 United Kingdom 1 United States 13 Global 75
Yancheng KangdiSen Pharmaceutical Co., Ltd.
Tel
13812573443
Fax
-
Email
tongbenwan22@163.com
Country
China
ProdList
1998
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4121
Advantage
55
Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
646
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
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View Lastest Price from SBE 13 hydrochloride manufacturers

Career Henan Chemical Co
Product
N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine,hydrochloride 1052532-15-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

1052532-15-6, SBE 13 hydrochlorideRelated Search:

SBE13

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  • SBE-13 HCl
  • N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine
  • N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride
  • CS-1632
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  • SBE 13 hydrochloride USP/EP/BP
  • N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine
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