SBE 13 hydrochloride

ChemicalBook > CAS DataBase List > SBE 13 hydrochloride

Product Name: SBE 13 hydrochloride
CAS No.: 1052532-15-6
Chemical Name: SBE 13 hydrochloride
Synonyms: CS-1632;SBE-13 HCl;SBE13 HydrochL;SBE 13 hydrochloride;SBE 13 hydrochloride USP/EP/BP;SBE 13 hydrochloride >=98% (HPLC);N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine;N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine;N-(4-((6-chloropyridin-3-yl)Methoxy)-3-Methoxybenzyl)-2-(3,4-diMethoxyphenyl)ethanaMine hydrochloride;N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride
CBNumber: CB82552606
Molecular Formula: C24H28Cl2N2O4
Formula Weight: 479.4
MOL File: 1052532-15-6.mol

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SBE 13 hydrochloride Property

storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: ≥17mg/mL
form: powder
color: white to tan

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0012
Product name: SBE 13 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2022/05/15

Cayman Chemical

Product number: 21241
Product name: SBE 13 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 21241
Product name: SBE 13 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 21241
Product name: SBE 13 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $232
Updated: 2024/03/01

Cayman Chemical

Product number: 21241
Product name: SBE 13 (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $421
Updated: 2024/03/01

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SBE 13 hydrochloride Chemical Properties,Usage,Production

Description

SBE 13 is a potent inhibitor of polo-like kinase 1 (Plk1) (IC₅₀ = 0.2 nM) that targets the inactive conformation of the enzyme . It exhibits no activity against aurora A kinase and less effectively inhibits Plk2 (IC₅₀ > 66 μM) and Plk3 (IC₅₀ = 875 nM). SBE 13 induces cell cycle arrest, reduces cell proliferation (EC₅₀ = 5-60 μM), and induces apoptosis in a broad range of human cancer cell lines.

Uses

SBE13 Hydrochloride is a selective inhibitor of PLK1.

in vitro

to determine its ability to induce cell death in cancer cells, we applied kinase assays, western blot analyses, facs can analyses, caspase assays and immunofluorescence studies. we detected decreased cell proliferation, delayed progression through the cell cycle in lower sbe13 concentrations, a g2/m arrest using higher sbe13 concentrations followed by apoptosis, and abnormal mitotic figures. notably, sbe13 did not influence activity of other kinases (plk2, plk3, aurora a), indicating the selectivity of this type ii plk1 inhibitor [1].

SBE 13 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SBE 13 hydrochloride manufacturers

Career Henan Chemical Co

Product: N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine,hydrochloride 1052532-15-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

1052532-15-6, SBE 13 hydrochlorideRelated Search:

SBE13

SBE 13 hydrochloride

N-(4-((6-chloropyridin-3-yl)Methoxy)-3-Methoxybenzyl)-2-(3,4-diMethoxyphenyl)ethanaMine hydrochloride

SBE-13 HCl

N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine

N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride

CS-1632

SBE13 HydrochL

SBE 13 hydrochloride >=98% (HPLC)

SBE 13 hydrochloride USP/EP/BP

N-(4-((6-chloropyridin-3-yl)methoxy)-3-methoxybenzyl)-2-(3,4-dimethoxyphenyl)ethanamine

Inhibitor,SBE13,Apoptosis,Polo-like Kinase (PLK),inhibit,SBE13 Hydrochloride,SBE 13,SBE-13 Hydrochloride,Autophagy,SBE-13

1052532-15-6

C24H27ClN2O4HCl

Inhibitors