Ivosidenib

Product Name: Ivosidenib
CAS No.: 1448347-49-6
Chemical Name: Ivosidenib
Synonyms: Ivosidenib;lvosidenib;RG120;CS-1721;EOS-60845;RG120 100MG;AG120;AG 120;AG-120 (RG120);Ivosidenib 13C5;Ivosidenib(AG-120)
CBNumber: CB32738771
Molecular Formula: C28H22ClF3N6O3
Formula Weight: 582.96
MOL File: 1448347-49-6.mol

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Ivosidenib Property

Melting point:: 151-173°C
Boiling point:: 854.3±65.0 °C(Predicted)
Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 11.58±0.40(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19894
Product name: AG-120
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19894
Product name: AG-120
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 19894
Product name: AG-120
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 19894
Product name: AG-120
Purity: ≥98%
Packaging: 25mg
Price: $381
Updated: 2024/03/01

ChemScene

Product number: CS-5122
Product name: Ivosidenib
Purity: 99.78%
Packaging: 50mg
Price: $384
Updated: 2021/12/16

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Ivosidenib Chemical Properties,Usage,Production

Description

AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) that specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of 2-hydroxyglutarate. AG-120 may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells.

Uses

Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers.

Definition

ChEBI: Ivosidenib is a tertiary carboxamide resulting from the formal condensation of the carboxy group of (2S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidine-2-carboxylic acid with the secondary amino group of (2S)-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-2-[(5-fluoropyridin-3-yl)amino]acetamide. It is approved by the FDA for the treatment of acute myeloid leukemia (AML) in patients with an isocitrate dehydrogenase-1 (IDH1) mutation. It has a role as an antineoplastic agent and an EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor. It is a member of monochlorobenzenes, a cyanopyridine, a member of pyrrolidin-2-ones, an organofluorine compound, a tertiary carboxamide and a secondary carboxamide.

in vitro

tf-1 cells or primary human aml patient samples expressing mutant idh1 were treated with ag-120, and the results showed that in tf-1 idh1-r132h cells, ag-120 was able to decrease the intracellular 2-hg levels, inhibit growth factor independent proliferation and restore erythropoietin-induced differentiation [1].

IC 50

< 100 nm

storage

Store at -20°C

References

[1] erica hansen et al. ag-120, an oral, selective, first-in-class, potent inhibitor of mutant idh1, reduces intracellular 2hg and induces cellular differentiation in tf-1 r132h cells and primary human idh1 mutant aml patient samples treated ex vivo. blood 2014 124:3734.
[2] http://www. aacr.org/newsroom/pages/news-release-detail.aspx itemid=789#.wlauom997iu

Ivosidenib Preparation Products And Raw materials

Raw materials

Preparation Products

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Ivosidenib Suppliers

China 134 India 5 United States 12 Global 151

Pharma Affiliates

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Email: @pharmaffiliates.com
Country: India
ProdList: 6754
Advantage: 58

SynZeal Research Pvt Ltd

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Email: standards@synzeal.com
Country: India
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Pharmaffiliates Analytics and Synthetics P. Ltd

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Email: mktg@pharmaffiliates.com
Country: India
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A.J Chemicals

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Email: sales@ajchem.in
Country: India
ProdList: 6100
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View Lastest Price from Ivosidenib manufacturers

Career Henan Chemical Co

Product: RG120 1448347-49-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-20

1448347-49-6, IvosidenibRelated Search:

Nintedanib GDC-0084 SH-4-54 Osimertinib mesylate Tazemetostat (EPZ-6438) Niraparib Mertansine (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate Enasidenib ABBV-075 Ponatinib Selonsertib

AG120;AG 120

RG120

Ivosidenib

CS-1721

lvosidenib

RG120 100MG

EOS-60845

Ivosidenib(AG-120)

(2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

(S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

(2S)-1-(4-Cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)glycinamide

Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-

Ivosidenib 13C5

(S)-N-[(S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyano-2-pyridyl)-N-(5-fluoro-3-pyridyl)-5-oxopyrrolidine-2-carboxamide

AG-120 (RG120)

1448347-49-6

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