AMG319

ChemicalBook > CAS DataBase List > AMG319

Product Name: AMG319
CAS No.: 1608125-21-8
Chemical Name: AMG319
Synonyms: AMG319;ACP319;ACP-319;CS-1593;ACP 319;AMG319 (ACP-319);AMG-319;AMG 319;AMG319;AMG319; AMG-319; AMG 319; ACP319; ACP-319; ACP 319;;AMG-319,AMG 319,Inhibitor,inhibit,PI3K,AMG319,Phosphoinositide 3-kinase;(S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine
CBNumber: CB32749524
Molecular Formula: C21H16FN7
Formula Weight: 385.4
MOL File: 1608125-21-8.mol

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AMG319 Property

Boiling point:: 708.3±60.0 °C(Predicted)
Density: 1.432±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 9.99±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17383
Product name: AMG 319
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17383
Product name: AMG 319
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 17383
Product name: AMG 319
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 17383
Product name: AMG 319
Purity: ≥98%
Packaging: 25mg
Price: $456
Updated: 2024/03/01

AK Scientific

Product number: 8894DT
Product name: N-((1S)-1-(7-Fluoro-2-(2-pyridyl)quinoline-3-yl)ethyl)-9H-purine-6-amine
Packaging: 5mg
Price: $252
Updated: 2021/12/16

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AMG319 Chemical Properties,Usage,Production

Biological Activity

amg 319, a highly selective inhibitor of phosphoinositide 3-kinase p110δ isoform (pi3kδ) [1], with an ic50 value less than 10 nm [2].pi3kδ plays an essential role in b-cell receptor (bcr) signaling. pi3kδ is expressed in lymphoid malignancies, including chronic lymphocytic leukemia (cll) and non-hodgkin lymphoma (nhl) [1].c-akt, a serine-threonine kinase is one target of pi39k. c-akt is the prototypical member of a mammalian akt isoform family. the regulation to akt may be phosphorylation or direct binding the akt pleckstrin homology domain with pi39k lipid products. pi39k-independent akt stimuli had been identified [3]. amg 319 inhibited basal akt phosphorylation and proliferation in lymphoid tumor cells [1].28 patients received amg 319. in a cll patient after 1 dose of amg 319, grade 3 hemolytic anemia at 25 mg was produced. all cll samples with an inducible signal (60%) showed coverage of bcr-induced pakt (ex-vivo igd stimulated) dose-dependently; at 400 mg, near complete inhibition was seen for 24 hours. baseline % of t-regulatory cells was elevated in cll patients (14.4% ± 7.6%). but during treatment (14/19 patients), the elevated t regulatory cells tended to normalize. this suggested that the drug might produce immune restoration. by physical exam, all 20 evaluable patients showed greater than 50% lymph node (ln) reduction, 15 (75%) patients showed greater than 90% ln reduction. this response was present in all cytogenetic subtypes [1].

References

[1]. glenn m, mato ar, allgood sd, et al. first-in-human study of amg 319, a highly selective, small molecule inhibitor of pi3kδ, in adult patients with relapsed or refractory lymphoid malignancies. blood, 2013, 122(21): 678-678.
[2]. brana i, siu ll. clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment. bmc medicine, 2012, 10(1): 1.
[3]. datta sr, dudek h, tao x, et al. akt phosphorylation of bad couples survival signals to the cell-intrinsic death machinery. cell, 1997, 91(2): 231-241.

AMG319 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AMG319 manufacturers

Career Henan Chemical Co

Product: AMG319 1608125-21-8
Price: US $1.00/KG
Min. Order: 1g
Purity: Min98% HPLC
Supply Ability: g/kg /ton
Release date: 2019-12-20

1608125-21-8, AMG319Related Search:

AC-55541 AC710

CS-1593

AMG-319;AMG 319;AMG319

AMG319

(alphaS)-7-Fluoro-alpha-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine

(S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine

(αS)--Fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine

ACP 319

ACP319

ACP-319

AMG319; AMG-319; AMG 319; ACP319; ACP-319; ACP 319;

3-Quinolinemethanamine, 7-fluoro-α-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-, (αS)-

AMG319 (ACP-319)

AMG-319,AMG 319,Inhibitor,inhibit,PI3K,AMG319,Phosphoinositide 3-kinase

1608125-21-8

608125-21-8

C21H16FN7