AC-55541

Product Name: AC-55541
CAS No.: 916170-19-9
Chemical Name: AC-55541
Synonyms: AOB2796;CS-1802;CS-2020;AC 55541;AC55541; AC-55541;AC-55541, 10 mM in DMSO;AC 55541, protease-activated receptor 2 (PAR2) agonist;AC 55541,inhibit,AC-55541,AC55541,Inhibitor,Protease Activated Receptor (PAR),Thrombin receptors;(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide;(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide
CBNumber: CB82518974
Molecular Formula: C25H20BrN5O3
Formula Weight: 518.36
MOL File: 916170-19-9.mol

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AC-55541 Property

Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO
form: powder
pka: 10.99±0.46(Predicted)
color: White to off-white

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Safety

WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H303May be harmfulif swallowed

H320Causes eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A3609
Product name: AC-55541
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $177
Updated: 2022/05/15

Cayman Chemical

Product number: 17736
Product name: AC-55541
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17736
Product name: AC-55541
Purity: ≥98%
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 17736
Product name: AC-55541
Purity: ≥98%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 17736
Product name: AC-55541
Purity: ≥98%
Packaging: 25mg
Price: $479
Updated: 2024/03/01

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AC-55541 Chemical Properties,Usage,Production

Uses

AC 55541 is a selective protease-activated receptor 2 agonist.

Definition

ChEBI: AC-55541 is an organic molecular entity.

Biological Activity

ac 55541 is a potent agonist of par2 with pec50 value of 6.7 and functions range from 200 to 1000 nm [1-3].protease-activated receptor 2 (par2) is a member of the large family of 7-transmembrane receptors and plays an important role in modulating inflammatory responses and acting as a sensor for proteolytic enzymes generated during infection [2].ac 55541 is a selective par2 agonist and has no effect on par1. using a cellular proliferation assay (r-sat), it showed that ac 55541 stimulated nih-3t3 cells proliferation by activating par2 and receptor with f240s mutation constitutively active in all functional assays which nearly 30-fold sensitive to ac 55541 than sligrl and 2-furorl ligrlo [1, 2]. when tested with human corneal epithelial (hce) cells, administration of ac 55541 significantly induced the expression of par2 and inhibited acanthamoeba plasminogen activator (apa) [3].in male sprague-dawley rat model with acute thermal nociception and edema in paw induced by sligrl-nh2 or trypsin, intrapaw administration of ac 55541 induced hind paw edema and thermal hyperalgesia at the doses as low as 30 ng and showed dose-dependent pronociceptive effects [1].

IC 50

PAR2

storage

Store at -20°C

References

1. gardell, l.r., et al., identification and characterization of novel small-molecule protease-activated receptor 2 agonists. j pharmacol exp ther, 2008. 327(3): p. 799-808.2. ma, j.n. and e.s. burstein, the protease activated receptor 2 (par2) polymorphic variant f240s constitutively activates par2 receptors and potentiates responses to small-molecule par2 agonists. j pharmacol exp ther, 2013. 347(3): p. 697-704.3. tripathi, t., m. abdi, and h. alizadeh, protease-activated receptor 2 (par2) is upregulated by acanthamoeba plasminogen activator (apa) and induces proinflammatory cytokine in human corneal epithelial cells. invest ophthalmol vis sci, 2014. 55(6): p. 3912-21.

AC-55541 Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-55541 Suppliers

China 74 India 1 United Kingdom 2 United States 16 Global 93

Shanghai Boyle Chemical Co., Ltd.

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Dalian Meilun Biotech Co., Ltd.

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Haoyuan Chemexpress Co., Ltd.

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Nanjing Dulai Biotechnology Co., Ltd.

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Shanghaizehan biopharma technology co., Ltd.

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D&C Chemicals

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EMMX Biotechnology LLC

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Pharmacodia (Beijing) Co.,Ltd

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916170-19-9, AC-55541Related Search:

AC710 AMG319

(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide

AC 55541

CS-2020

CS-1802

AC 55541,(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide

(E)-N-(2-(2-(1-(3-Bromophenyl)ethylidene)hydrazinyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide

AC55541; AC-55541

(2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide AC55541

AOB2796

alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide

1-Phthalazineacetic acid, α-(benzoylamino)-3,4-dihydro-4-oxo-, (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide

AC 55541,inhibit,AC-55541,AC55541,Inhibitor,Protease Activated Receptor (PAR),Thrombin receptors

(E)-N-(2-(2-(1-(3-Bromophenyl)ethylidene)hydrazineyl)-2-oxo-1-(4-oxo-3,4-dihydrophthalazin-1-yl)ethyl)benzamide

N-({N'-[(1E)-1-(3-bromophenyl)ethylidene]hydrazinecarbonyl}(4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide

AC 55541, protease-activated receptor 2 (PAR2) agonist

AC-55541, 10 mM in DMSO

(2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide

916170-19-9

C25H20BrN5O3

Inhibitors