NSC 600157

Product Name: NSC 600157
CAS No.: 31083-55-3
Chemical Name: NSC 600157
Synonyms: PRT4165;NSC 600157;PRT 4165(NSC 600157);PRT4165 >=98% (HPLC);2-(3-Pyridylmethylene)-1,3-indandione; 2-(pyridin-3-ylmethylidene)indene-1,3-dione;2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione;2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione;1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-;PRT 4165; PRT-4165; NSC600157; NSC-600157; NSC 600157
CBNumber: CB32750711
Molecular Formula: C15H9NO2
Formula Weight: 235.24
MOL File: 31083-55-3.mol

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NSC 600157 Property

Melting point:: 154-161 °C(Solv: ethanol (64-17-5))
Boiling point:: 377.63°C (rough estimate)
Density: 1.1757 (rough estimate)
refractive index: 1.6231 (estimate)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
pka: 3.24±0.12(Predicted)
form: powder
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

WGK Germany: 3
RTECS: NK6710000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1013
Product name: PRT4165
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1013
Product name: PRT4165
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $417
Updated: 2024/03/01

Sigma-Aldrich

Product number: EME00468
Product name: (2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-indene-1,3-dione
Packaging: 1G
Price: $1210
Updated: 2023/06/20

Cayman Chemical

Product number: 19093
Product name: PRT4165
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 19093
Product name: PRT4165
Purity: ≥98%
Packaging: 10mg
Price: $85
Updated: 2024/03/01

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NSC 600157 Chemical Properties,Usage,Production

Description

PRT-4165 (31083-55-3) is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50?= 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1?PRT-4165 inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination?in vitro?and?in vivo?and as such represents a new tool for studying chromatin remodeling.2

Biochem/physiol Actions

PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX.

storage

Store at +4°C

References

1) Alchanati?et al. (2009),?The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex – a potentially new drug target; PLoS One,?4?e8104 2) Ismail?et al.?(2013),?A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks; J. Biol. Chem.,?288?26944

NSC 600157 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC 600157 Suppliers

China 77 India 1 United Kingdom 2 United States 15 Global 95

Shandong Jirun Biomedical Technology Co., Ltd.

Tel: 0539-0539-8613587 17661611089
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Shanghai Boyle Chemical Co., Ltd.

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Fax: 86-21-57758967
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MedChemexpress LLC

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Country: United States
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Guangzhou Isun Pharmaceutical Co., Ltd

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TargetMol Chemicals Inc.

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AdooQ Bioscience CHINA

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Shanghai JiYi Biotechnology Co. Ltd.

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Sigma-Aldrich

Tel: 021-61415566 800-8193336
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Shanghai Lollane Biological Technology Co.,Ltd.

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D&C Chemicals

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View Lastest Price from NSC 600157 manufacturers

Career Henan Chemical Co

Product: 2-(pyridin-3-ylmethylidene)indene-1,3-dione 31083-55-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

31083-55-3, NSC 600157Related Search:

C 646 Daminozide RVX-208 5-Azacytidine 1,3-Butadiene, 2,3-dichloro-, homopolymer, brominated PRT-060318

PRT 4165; PRT-4165; NSC600157; NSC-600157; NSC 600157

2-(pyridin-3-ylmethylidene)indene-1,3-dione

2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione

2-(3-Pyridylmethylene)-1,3-indandione

NSC 600157

PRT4165

PRT 4165(NSC 600157)

1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-

PRT4165 >=98% (HPLC)

2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione

31083-55-3