ChemicalBook > CAS DataBase List > 1,2,3-1H-Triazole

1,2,3-1H-Triazole

Description

Product Name: 1,2,3-1H-Triazole
CAS No.: 288-36-8
Chemical Name: 1,2,3-1H-Triazole
Synonyms: 1,2,3-TRIAZOLE;1H-1,2,3-TRIAZOLE;2H-1,2,3-Triazole;Osotriazole;2H-Triazole;1h-1,2,3-Trizole;Triazacyclopentadiene;V-triazole;3-Triazole;vic-triazole
CBNumber: CB3290804
Molecular Formula: C2H3N3
Formula Weight: 69.07
MOL File: 288-36-8.mol

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1,2,3-1H-Triazole Property

Melting point:: 23-25 °C(lit.)
Boiling point:: 203 °C752 mm Hg(lit.)
Density: 1.192 g/mL at 25 °C(lit.)
refractive index: n20/D 1.498(lit.)
Flash point:: 225 °F
storage temp.: Sealed in dry,Room Temperature
solubility: Acetone, Chloroform, Methanol (Slightly)
form: Liquid
pka: 1.17(at 20℃)
color: Clear colorless to yellow
Specific Gravity: 1.192
Water Solubility: soluble
FreezingPoint: 21.0 to 24.0 ℃
BRN: 104766
InChIKey: QWENRTYMTSOGBR-UHFFFAOYSA-N
CAS DataBase Reference: 288-36-8(CAS DataBase Reference)
NIST Chemistry Reference: 1H-1,2,3-Triazole(288-36-8)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-63-36-22
Safety Statements: 37/39-26-36/37
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 333662
Product name: 1H-1,2,3-Triazole
Purity: 97%
Packaging: 1g
Price: $56.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 333662
Product name: 1H-1,2,3-Triazole
Purity: 97%
Packaging: 5g
Price: $154
Updated: 2025/07/31

TCI Chemical

Product number: T1880
Product name: 1H-1,2,3-Triazole
Purity: >98.0%(T)
Packaging: 5g
Price: $115
Updated: 2025/07/31

TCI Chemical

Product number: T1880
Product name: 1H-1,2,3-Triazole
Purity: >98.0%(T)
Packaging: 25g
Price: $403
Updated: 2025/07/31

TRC

Product number: T767390
Product name: 1H-1,2,3-Triazole
Packaging: 100g
Price: $1205
Updated: 2021/12/16

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1,2,3-1H-Triazole Chemical Properties,Usage,Production

Description

1,2,3-1H-Triazole is a kind of azole compound. It can effectively promote the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. It is also a useful triazole for proteomics research¹. It also find use in research as a bioisostere in medicinal chemistry as well as an building block for more complex chemical compounds, including pharmaceutical drugs such as mubritinib and tazobactam². It is a main class of hetero-cycles because of its extensive range of biological properties such as antimicrobial, anticancer, anti-tubercular, anti-HIV, antimalarial, antibacterial, antifungal, antiviral and anti-diabetic property³.

Chemical Properties

clear colorless liquid

Uses

A basic 5-membered aromatic heterocycle used as a building block for more complex pharmaceutical compounds. There have been recent studies that showed antitumor, antiinflammatory, analgesic, antifunga l, antibacterial and antiviral activities in bioactive triazoles.

Uses

It effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. A useful triazole for proteomics research

Definition

ChEBI: 1H-1,2,3-triazole is a 1,2,3-triazole. It is a tautomer of a 2H-1,2,3-triazole and a 4H-1,2,3-triazole.

Synthesis Reference(s)

The Journal of Organic Chemistry, 62, p. 9177, 1997 DOI: 10.1021/jo971313o

General Description

2H-1,2,3-triazole is tautomeric form of 1H-1,2,3-triazole. 1H-1,2,3-triazole effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism.

Synthesis

4546-95-6

288-36-8

General procedure for the synthesis of 1,2,3-triazole from 1H-1,2,3-triazole-4,5-dicarboxylic acid: to a 2000 mL four-neck flask was added 1250 mL of pure water and 157.08 g (1.0 mol) of 1H-1,2,3-triazole-4,5-dicarboxylic acid, followed by the addition of 4.71 g (equivalent to 1H-1,2,3-triazole-4,5-dicarboxylic acid 3% by mass) of N,N-diisopropylethylamine. The reaction mixture was heated to 100~110°C under atmospheric pressure and refluxed until the reaction solution was clarified. Refluxing was continued for 1 h. The reaction was monitored by HPLC and terminated when the residue of 1H-1,2,3-triazole-4,5-dicarboxylic acid was less than 1%. After completion of the reaction, filtration was performed. A vacuum pump was used to remove most of the water from the filtrate, which was then replaced with a mechanical pump for high vacuum dehydration. The four-necked flask was mounted on a distillation apparatus and vacuum distillation was carried out, resulting in 66.48 g of 1H-1,2,3-triazole with a molar yield of 96.25% and a GC purity of 99.56%.

References

[1] Patent: CN106946803, 2017, A. Location in patent: Paragraph 0035; 0040; 0041; 0045; 0046; 0050; 0051
[2] Patent: CN105330607, 2016, A. Location in patent: Paragraph 0033; 0034
[3] Chemische Berichte, 1893, vol. 26, p. 2737

1,2,3-1H-Triazole Preparation Products And Raw materials

Raw materials

Preparation Products

3-(1H-1,2,4-TRIAZOL-1-YL)PROPANOIC ACID

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View Lastest Price from 1,2,3-1H-Triazole manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1,2,3-1H-Triazole 288-36-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 1,2,3-1H-Triazole 288-36-8
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-20

Hebei Yanxi Chemical Co., Ltd.

Product: 1,2,3-1H-Triazole 288-36-8
Price: US $100.00-50.00/kgkg
Min. Order: 1kgkg
Purity: 0.99
Supply Ability: 10000
Release date: 2023-09-28

288-36-8, 1,2,3-1H-TriazoleRelated Search:

1H-Benzotriazole 3-Amino-1,2,4-Triazole 5-Methyl-1H-benzotriazole 1,2,4-Triazole Tolyltriazole Tazobactam acid TBTA BENZHYDRYL 6,6-DIHYDROPENICILLIC ACID 1-OXIDE[TAZOBACTAM INTERMEDIATE] Benzophenone hydrazone Tazobactam Acid Impurity 16 Tazobactam Impurity B Tazobactam Impurity 5 Tazobactam Acid Impurity 14 Tazobactam Acid Impurity 12 Tazobactam Diphenylmethyl Ester (2S,5R)-3α-Chloromethyl-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid benzhydryl ester 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-bromo-3,3-dimethyl-7-oxo-, diphenylmethyl ester, 4-oxide, (2S,5R,6S)- [2S-(2alpha,5alpha,6alpha)]-6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

LABOTEST-BB LT02056574

1H-1,2,3-TRIAZOLE

1,2,3-TRIAZOLE

1,2,3-1H-TRIAZOLE

TRIAZOLE(1,2,3-)

1,2,3-Triazol

1H-1,2,3-Triazol

Osotriazole

Triazacyclopentadiene

V-triazole

RIBAVIRIN USP24

1h-1,2,3-Trizole

1H-1,2,3-Triazole,98%

vic-triazole

2H-1,2,3-Triazole

2H-Triazole

1,2,3-1H-Triazole,97%

3-Triazole

2,3-Diazapyrrole

v-Triazole (7CI,8CI)

1H,2H-<1,2,3>TriazoliuMyl-(5)-Zwitterion

1,2,3-Triazole, 97+%

1<i>H</i>-1,2,3-Triazole

H-1,2,3-Triazole

Fluconazole Impurity 21

1, 2, 3-triazoles

JACS-288-36-8

triazole fiona

Tazobactam Acid Impurity 23 (1,2,3-1H-Triazole)

Tazobactam Impurity 42

1,2,3-1H-Triazole USP/EP/BP

1H-1,2,3-Triazole (9CI, ACI)

1,2,3-1H-TRIAZOLE 99%

288-36-8

C2H3N3

C2H3N3liquid

Heterocyclic Building Blocks

Triazoles

Building Blocks

Aromatics

Heterocycles

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Pharmaceuticals

Building Blocks

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