4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE
- Product Name
- 4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE
- CAS No.
- 141337-26-0
- Chemical Name
- 4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE
- Synonyms
- 4-chloro benzene sulfonul chloride;4-Chlor0-2-Fluorobenzen sulfonyl chloride;2-fluoro-4-Chlorobenzenesulfonyl chloride;4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE;4-CHLORO-2-FLUOROBENZENESULPHONYL CHLORIDE;2-Fluoro,4-chloro benzene sulfonul chloride;4-Choro-2-fluorobenzene-1-sulfonyl chloride;4-chloro-2-fluorobenzene-1-sulfonyl chloride;4-Chloro-2-fluorobenzenesulphonylchloride97%;Benzenesulfonyl chloride, 4-chloro-2-fluoro-
- CBNumber
- CB3293603
- Molecular Formula
- C6H3Cl2FO2S
- Formula Weight
- 229.06
- MOL File
- 141337-26-0.mol
4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE Property
- Melting point:
- 34-38 °C(lit.)
- Boiling point:
- 257.4±20.0℃ (760 Torr)
- Density
- 1.610±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystals
- color
- White
- Sensitive
- Moisture Sensitive
- CAS DataBase Reference
- 141337-26-0(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 555983
- Product name
- 4-Chloro-2-fluorobenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $30
- Updated
- 2023/06/20
- Product number
- C382520
- Product name
- 4-Chloro-2-fluorobenzene-1-sulfonylChloride
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- C382520
- Product name
- 4-Chloro-2-fluorobenzene-1-sulfonylChloride
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC10630
- Product name
- 4-Chloro-2-fluorobenzenesulphonyl chloride
- Packaging
- 2g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- PC9617
- Product name
- 4-Chloro-2-fluorobenzenesulphonylchloride
- Purity
- 96%
- Packaging
- 5g
- Price
- $34
- Updated
- 2021/12/16
4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE Chemical Properties,Usage,Production
Uses
4-Chloro-2-fluorobenzenesulfonyl chloride (4-chloro-2-fluorobenzene-1-sulfonyl chloride) may be used to synthesize [1-(4-chloro-2-fluorophenylsulfonyl) piperidin-4-yl] diphenylmethanol.
Synthesis
57946-56-2
141337-26-0
General procedure for the synthesis of 4-chloro-2-fluorobenzenesulfonyl chloride from 4-chloro-2-fluoroaniline: 1. 4-Chloro-2-fluoroaniline (22.90 g, 151 mmol) was dissolved in 120 mL of acetic acid and 80 mL of concentrated hydrochloric acid was added with stirring. 2. the reaction mixture was cooled to 0 °C and a solution of sodium nitrite (27.2 g, 0.4 mol) dissolved in 40 mL of water was added over 10 minutes. 3. The reaction mixture was stirred at 0 °C for 30 min. 4. in another flask, cuprous chloride (500 mg) was dissolved in 200 mL of acetic acid. 5. The flask was cooled to 0 °C and sulfur dioxide gas was passed into the solution for 40 min. 6. The diazonium salt solution prepared in step 3 was slowly added to the solution containing cuprous chloride and sulfur dioxide over a period of 20 minutes, at which time vigorous gas escape was observed. 7. After the addition, the ice bath is removed and the reaction mixture is allowed to gradually warm to room temperature. 8. The reaction mixture was poured into 500 g of crushed ice and the precipitated solid product was collected, washed and dried to give 26.1 g (73% yield) of 4-chloro-2-fluorobenzenesulfonyl chloride.
References
[1] Patent: US2003/232859, 2003, A1. Location in patent: Page 56
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 22, p. 9539 - 9553
4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE manufacturers
- Product
- 4-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE 141337-26-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-29