4-Fluorobenzenesulfonyl chloride
- Product Name
- 4-Fluorobenzenesulfonyl chloride
- CAS No.
- 349-88-2
- Chemical Name
- 4-Fluorobenzenesulfonyl chloride
- Synonyms
- uorobenzenesuL;4-Fluorobenzenesulfonyl;P-Fluorophenyl chloride;4-Fluorbenzolsulfonylchlorid;chloro(4-fluorophenyl)sulfone;4-fluoro-benzenesulfonylchlorid;Benzenesulfonyl chloride, 4-f;4-FLUOROBENZENSULFONYL CHLORIDE;4-Fluorophenylsulfonyl chloride;p-Fluorophenylsulfonyl chloride
- CBNumber
- CB2233466
- Molecular Formula
- C6H4ClFO2S
- Formula Weight
- 194.61
- MOL File
- 349-88-2.mol
4-Fluorobenzenesulfonyl chloride Property
- Melting point:
- 29-31 °C (lit.)
- Boiling point:
- 95-96 °C/2 mmHg (lit.)
- Density
- 1.467 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- dioxane: 0.1 g/mL, clear
- form
- Crystalline Low Melting Mass
- color
- White to light brown
- Sensitive
- Moisture Sensitive
- BRN
- 2091633
- Stability:
- Moisture Sensitive
- InChI
- InChI=1S/C6H4ClFO2S/c7-11(9,10)6-3-1-5(8)2-4-6/h1-4H
- InChIKey
- BFXHJFKKRGVUMU-UHFFFAOYSA-N
- SMILES
- C1(S(Cl)(=O)=O)=CC=C(F)C=C1
- CAS DataBase Reference
- 349-88-2(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenesulfonyl chloride, 4-fluoro- (349-88-2)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-28-36/37/39-45-28A-27
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Corrosive
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- F6206
- Product name
- 4-Fluorobenzenesulfonyl chloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $30.3
- Updated
- 2025/07/31
- Product number
- F6206
- Product name
- 4-Fluorobenzenesulfonyl chloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $86.9
- Updated
- 2025/07/31
- Product number
- F0202
- Product name
- 4-Fluorobenzenesulfonyl Chloride
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- F0202
- Product name
- 4-Fluorobenzenesulfonyl Chloride
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $57
- Updated
- 2025/07/31
- Product number
- F6206
- Product name
- 4-Fluorobenzenesulfonyl chloride
- Purity
- 98%
- Packaging
- 100g
- Price
- $242
- Updated
- 2025/07/31
4-Fluorobenzenesulfonyl chloride Chemical Properties,Usage,Production
Chemical Properties
white to light brown crystalline low melting mass
Uses
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
Synthesis
371-42-6
349-88-2
The general procedure for the synthesis of 4-fluorobenzenesulfonyl chloride from p-fluorobenzenethiol is as follows: a mixture of mercaptan (1 mmol), 30% H2O2 (3 mmol, 0.3 mL), and TiCl4 (1 mmol, 0.11 mL) was reacted in CH3CN with stirring at 25 °C for the time referred to in Table 1.The reaction was carried out by the immediate precipitation of white solid (TiO2) . The progress of the reaction was monitored by TLC, and upon completion of the reaction, the reaction mixture was quenched by the addition of H2O (10 mL) and subsequently extracted with EtOAc (4 × 5 mL). The organic phases were combined and dried with anhydrous MgSO4. The filtrate was concentrated under reduced pressure to give an analytically pure product. The product can be further purified by short silica gel column chromatography and structurally confirmed by 1H NMR, 13C NMR spectroscopic analysis and comparison of melting points with real samples prepared by known methods.
References
[1] Journal of Organic Chemistry, 2009, vol. 74, # 24, p. 9287 - 9291
[2] Synlett, 2009, # 17, p. 2773 - 2776
[3] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 10, p. 3692 - 3695
[4] Phosphorus, Sulfur and Silicon and the Related Elements, 2012, vol. 187, # 6, p. 769 - 775
[5] Journal of Organic Chemistry, 2007, vol. 72, # 15, p. 5847 - 5850
4-Fluorobenzenesulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluorobenzenesulfonyl chloride manufacturers
- Product
- 4-Fluorobenzenesulfonyl chloride 349-88-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-27
- Product
- 4-Fluorobenzene Sulfonyl Chloride 349-88-2
- Price
- US $20.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 300 Tons/ year
- Release date
- 2019-12-25
- Product
- 4-Fluorobenzenesulfonyl chloride 349-88-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- As your request
- Release date
- 2025-03-14