3-Nitrobenzenesulfonyl chloride Property

Melting point:

61-62 °C(lit.)

Boiling point:

approximate 341℃

Density 

1.602 (estimate)

refractive index 

1.6000 (estimate)

Flash point:

>110°C

storage temp. 

Store below +30°C.

form 

Crystalline Powder

color 

Light beige to yellow

Water Solubility 

Decomposes

Sensitive 

Moisture Sensitive

BRN 

746542

InChIKey

MWWNNNAOGWPTQY-UHFFFAOYSA-N

CAS DataBase Reference

121-51-7(CAS DataBase Reference)

NIST Chemistry Reference

M-nitrobenzene sulfonyl chloride(121-51-7)

EPA Substance Registry System

Benzenesulfonyl chloride, 3-nitro- (121-51-7)

Safety

Hazard Codes 

C

Risk Statements 

34-29-14

Safety Statements 

26-36/37/39-45-8

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

21

Hazard Note 

Corrosive

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29049090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

3-Nitrobenzenesulfonyl chloride Chemical Properties,Usage,Production

Chemical Properties

light beige to yellow crystalline powder

Uses

It is employed as a biochemical for proteomics research. It is also used in the preparation of: acyl-2-aminobenzimidazole analogs and 6-chloro-2-methyl-3-{1-[(3-nitrophenyl)sulfonyl]-1H-pyrazol-3-yl}imidazo[1,2-a]pyridine.

Production Methods

Nitrobenzene is added to excess chlorosulfonic acid, and the temperature is raised gradually to 100 ℃ and held there for 6 h. After cooling, the mixture is poured into ice and water, and 3-nitrobenzenesulfonyl chloride is filtered off in 75 % yield for use as a paste, after being washed (to remove acid) with cold water.