N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE

Product Name: N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE
CAS No.: 143457-40-3
Chemical Name: N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE
Synonyms: TAPI-O;TAPI-0;(S,S)-TAPI-0;TNF-ALPHA PROTEASE INHIBITOR-O;TNF-ALPHA PROTEASE INHIBITOR-0;TAPI-0 (TNF-± processing inhibitor-0);HONHCOCH2CH(CH2-CH(CH3)2)CO-NAL-ALA-NH2;TAPI-0 (TNF alpha processing inhibitor-0);N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE;TAPI-0 (TNF alpha processing inhibitor-0), Matrix metalloprotease (MMP) and TACE inhibitor
CBNumber: CB3299443
Molecular Formula: C24H32N4O5
Formula Weight: 456.53
MOL File: Mol file

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N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE Property

Density: 1.227±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: 50% acetic acid: 1mg/mL
DMSO: 5mg/mL
form: White powder.
pka: 9.17±0.20(Predicted)
color: white
InChIKey: CRCPLBFLOSEABN-VBSNWNEZSA-N
SMILES: N(O)C(=O)CC(CC(C)C)C(=O)N[C@@H](Cc1cc2c(cc1)cccc2)C(=O)N[C@@H](C)C(=O)N

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Safety

WGK Germany: WGK 1
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 579050
Product name: TAPI-0 - CAS 143457-40-3 - Calbiochem
Packaging: 1mg
Price: $540
Updated: 2026/04/30

aablocks

Product number: AA006UX0
Product name: TAPI-0
Purity: >95%
Packaging: 1mg
Price: $568
Updated: 2026/05/28

DC Chemicals

Product number: DC8132
Product name: TAPI-0 (TNF-α processing inhibitor-0)
Purity: >98%
Packaging: 100mg
Price: $900
Updated: 2026/05/24

DC Chemicals

Product number: DC8132
Product name: TAPI-0 (TNF-α processing inhibitor-0)
Purity: >98%
Packaging: 250mg
Price: $1700
Updated: 2026/05/24

DC Chemicals

Product number: DC8132
Product name: TAPI-0 (TNF-α processing inhibitor-0)
Purity: >98%
Packaging: 1g
Price: $3200
Updated: 2026/05/24

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N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE Chemical Properties,Usage,Production

Uses

TAPI-0 is an inhibitor which blocks the maturation of cytokines, soluble cyokine receptors and other proteins that require the action of proteases.

Biological Activity

Cell permeable: no', 'Primary Target
TNF-α converting enzyme/ADAM17', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 100 nM against TACE (TNF-α converting enzyme/ADAM17)

N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE Suppliers

China 51 India 1 Japan 1 United States 9 Global 62

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143457-40-3, N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDERelated Search:

HONHCOCH2CH(CH2-CH(CH3)2)CO-NAL-ALA-NH2

TAPI-0

TAPI-O

N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-3-(2'-NAPHTHYL) ALANYL-L-ALANINE AMIDE

N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE

TNF-ALPHA PROTEASE INHIBITOR-0

TNF-ALPHA PROTEASE INHIBITOR-O

TAPI-0 (TNF-± processing inhibitor-0)

L-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl- (9CI)

N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1- oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide

TAPI-0 (TNF alpha processing inhibitor-0)

TAPI-0 (TNF alpha processing inhibitor-0), Matrix metalloprotease (MMP) and TACE inhibitor

(S,S)-TAPI-0

143457-40-3

A hydroxamate-based inhibitor of collagenase, gelatinase, and TACE