2-Nitro-1-naphthol
- Product Name
- 2-Nitro-1-naphthol
- CAS No.
- 607-24-9
- Chemical Name
- 2-Nitro-1-naphthol
- Synonyms
- 2-Nitro-1-Napthol;2-Nitro-2-naphthol;2-Nitronaphth-1-ol;2-NITRO-1-NAPHTHOL;2-Nitro-1-naphthol 95%;2-Nitro-1-naphthol,98%;2-Nitronaphthalen-1-ol;1-Naphthalenol, 2-nitro-;(S)-1-[()-2-(di-tert.-Butylphosphino)ferrocenylethylbis(2-
- CBNumber
- CB3300992
- Molecular Formula
- C10H7NO3
- Formula Weight
- 189.17
- MOL File
- 607-24-9.mol
2-Nitro-1-naphthol Property
- Melting point:
- 123-125 °C (lit.)
- Boiling point:
- 324.41°C (rough estimate)
- Density
- 1.3175 (rough estimate)
- refractive index
- 1.5400 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Powder
- pka
- 6.13±0.50(Predicted)
- InChI
- InChI=1S/C10H7NO3/c12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h1-6,12H
- InChIKey
- MUCCHGOWMZTLHK-UHFFFAOYSA-N
- SMILES
- C1(O)=C2C(C=CC=C2)=CC=C1[N+]([O-])=O
- CAS DataBase Reference
- 607-24-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Nitro-1-naphthol(607-24-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-24/25-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29089990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 161152
- Product name
- 2-Nitro-1-naphthol
- Purity
- 95%
- Packaging
- 5g
- Price
- $258
- Updated
- 2024/03/01
- Product number
- N496858
- Product name
- 2-Nitro-1-naphthol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- JK360787
- Product name
- 2-Nitro-1-naphthol
- Purity
- 98%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 4654-1-V6
- Product name
- 2-Nitro-1-naphthol
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- CS-W007968
- Product name
- 2-Nitro-1-naphthol
- Purity
- >97.0%
- Packaging
- 10g
- Price
- $49
- Updated
- 2021/12/16
2-Nitro-1-naphthol Chemical Properties,Usage,Production
Description
2-Nitro-1-naphthol is an important organic compound with anti-inflammatory properties used as an analytical method for measuring albumin concentration and as an enzyme-labelled substrate in electrochemical immunoassays. The substance reacts with albumin to form a coloured complex which can be detected spectrophotometrically. It is also used as a model system for the study of inflammatory diseases and inhibits p38 kinase activity. In addition, a derivative of 2-Nitro-1-naphthol (4-nitro-1-naphthol) can be used to prepare chromogenic substrates for neutral or slightly acidic hydrolases.
Chemical Properties
yellow-green to ochre-brown powder and/or chunks
Uses
2-Nitro-1-naphthol was employed as substrate for use in an amperometric 3-electrode system for the determination of alkaline phosphatase, the enzyme label most commonly used in electrochemical immunoassays. It was also used in the preparation of:
- di-(2-nitro-1-naphthyl) hydrogen phosphate
- 1-(2′-methyl-3′-indenyl)-2-naphthylamine and -2-naphthol (axially chiral ligands)
Application
2-Nitro-1-naphthol is commonly used as an intermediate in organic synthesis. It is a derivative of 1-nitro-2-naphthol and 4-nitro-1-naphthol. 1-Nitro-2-naphthol has been found to be a potent inhibitor of enzyme-dependent activation of acetyl-CoA, while 4-nitro-1-naphthol facilitates the preparation of chromogenic substrates for neutral or slightly acidic hydrolases[1-2].
Purification Methods
Crystallise the naphthol (repeatedly) from EtOH. [Beilstein 6 H 615, 6 III 2938, 6 IV 4236.]
References
[1] JIZHENG DANG . Chromogenic substrate from 4-nitro-1-naphthol for hydrolytic enzyme of neutral or slightly acidic optimum pH: 4-Nitro-1-naphthyl-β-d-galactopyranoside as an example[J]. Bioorganic & Medicinal Chemistry Letters, 2013. DOI:10.1016/j.bmcl.2012.11.120.
[2] ATSUKO SHINOHARA. Inhibition of acetyl-coenzyme A dependent activation of N-hydroxyarylamines by phenolic compounds, pentachlorophenol and 1-nitro-2-naphthol[J]. Chemico-Biological Interactions, 1986. DOI:10.1016/0009-2797(86)90058-X.
2-Nitro-1-naphthol Preparation Products And Raw materials
Raw materials
Preparation Products
2-Nitro-1-naphthol Suppliers
- Tel
- --
- Fax
- --
- info@acros.com
- Country
- Belgium
- ProdList
- 6772
- Advantage
- 81
View Lastest Price from 2-Nitro-1-naphthol manufacturers
- Product
- 2-Nitro-1-naphthol 607-24-9
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 2-Nitro-1-naphthol 607-24-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-28
- Product
- 2-Nitro-1-naphthol 607-24-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.4%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21