2-Nitro-1-naphthol

ChemicalBook > CAS DataBase List > 2-Nitro-1-naphthol

2-Nitro-1-naphthol

Product Name: 2-Nitro-1-naphthol
CAS No.: 607-24-9
Chemical Name: 2-Nitro-1-naphthol
Synonyms: 2-Nitro-1-Napthol;2-Nitro-2-naphthol;2-Nitronaphth-1-ol;2-NITRO-1-NAPHTHOL;2-Nitro-1-naphthol 95%;2-Nitro-1-naphthol,98%;2-Nitronaphthalen-1-ol;1-Naphthalenol, 2-nitro-
CBNumber: CB3300992
Molecular Formula: C10H7NO3
Formula Weight: 189.17
MOL File: 607-24-9.mol

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2-Nitro-1-naphthol Property

Melting point:: 123-125 °C (lit.)
Boiling point:: 324.41°C (rough estimate)
Density: 1.3175 (rough estimate)
refractive index: 1.5400 (estimate)
storage temp.: Sealed in dry,Room Temperature
form: Powder
pka: 6.13±0.50(Predicted)
InChI: InChI=1S/C10H7NO3/c12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h1-6,12H
InChIKey: MUCCHGOWMZTLHK-UHFFFAOYSA-N
SMILES: C1(O)=C2C(C=CC=C2)=CC=C1[N+]([O-])=O
CAS DataBase Reference: 607-24-9(CAS DataBase Reference)
NIST Chemistry Reference: 2-Nitro-1-naphthol(607-24-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-24/25-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29089990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 161152
Product name: 2-Nitro-1-naphthol
Purity: 95%
Packaging: 5g
Price: $258
Updated: 2024/03/01

TRC

Product number: N496858
Product name: 2-Nitro-1-naphthol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK360787
Product name: 2-Nitro-1-naphthol
Purity: 98%
Packaging: 1g
Price: $20
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-1-V6
Product name: 2-Nitro-1-naphthol
Packaging: 1g
Price: $29
Updated: 2021/12/16

ChemScene

Product number: CS-W007968
Product name: 2-Nitro-1-naphthol
Purity: >97.0%
Packaging: 10g
Price: $49
Updated: 2021/12/16

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2-Nitro-1-naphthol Chemical Properties,Usage,Production

Description

2-Nitro-1-naphthol is an important organic compound with anti-inflammatory properties used as an analytical method for measuring albumin concentration and as an enzyme-labelled substrate in electrochemical immunoassays. The substance reacts with albumin to form a coloured complex which can be detected spectrophotometrically. It is also used as a model system for the study of inflammatory diseases and inhibits p38 kinase activity. In addition, a derivative of 2-Nitro-1-naphthol (4-nitro-1-naphthol) can be used to prepare chromogenic substrates for neutral or slightly acidic hydrolases.

Chemical Properties

yellow-green to ochre-brown powder and/or chunks

Uses

2-Nitro-1-naphthol was employed as substrate for use in an amperometric 3-electrode system for the determination of alkaline phosphatase, the enzyme label most commonly used in electrochemical immunoassays. It was also used in the preparation of:

di-(2-nitro-1-naphthyl) hydrogen phosphate
1-(2′-methyl-3′-indenyl)-2-naphthylamine and -2-naphthol (axially chiral ligands)

Application

2-Nitro-1-naphthol is commonly used as an intermediate in organic synthesis. It is a derivative of 1-nitro-2-naphthol and 4-nitro-1-naphthol. 1-Nitro-2-naphthol has been found to be a potent inhibitor of enzyme-dependent activation of acetyl-CoA, while 4-nitro-1-naphthol facilitates the preparation of chromogenic substrates for neutral or slightly acidic hydrolases^[1-2].

Purification Methods

Crystallise the naphthol (repeatedly) from EtOH. [Beilstein 6 H 615, 6 III 2938, 6 IV 4236.]

References

[1] JIZHENG DANG . Chromogenic substrate from 4-nitro-1-naphthol for hydrolytic enzyme of neutral or slightly acidic optimum pH: 4-Nitro-1-naphthyl-β-d-galactopyranoside as an example[J]. Bioorganic & Medicinal Chemistry Letters, 2013. DOI:10.1016/j.bmcl.2012.11.120.
[2] ATSUKO SHINOHARA. Inhibition of acetyl-coenzyme A dependent activation of N-hydroxyarylamines by phenolic compounds, pentachlorophenol and 1-nitro-2-naphthol[J]. Chemico-Biological Interactions, 1986. DOI:10.1016/0009-2797(86)90058-X.

2-Nitro-1-naphthol Preparation Products And Raw materials

Raw materials

2-Nitroso-1-naphthol

Preparation Products

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2-Nitro-1-naphthol Suppliers

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View Lastest Price from 2-Nitro-1-naphthol manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Nitro-1-naphthol 607-24-9
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Nitro-1-naphthol 607-24-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-28

Honest Joy Holdings Limited

Product: 2-Nitro-1-naphthol 607-24-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.4%
Supply Ability: 100 tons
Release date: 2022-02-21

607-24-9, 2-Nitro-1-naphtholRelated Search:

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2-NITRO-1-NAPHTHOL

2-Nitro-1-Napthol

2-Nitronaphth-1-ol

2-Nitro-2-naphthol

1-Naphthalenol, 2-nitro-

2-Nitronaphthalen-1-ol

2-Nitro-1-naphthol,98%

2-Nitro-1-naphthol 95%

607-24-9

C10H6NO3

O2NC10H6OH

Building Blocks

Organic Building Blocks

Oxygen Compounds

Phenols

Building Blocks

C9 to C20+

Chemical Synthesis

Organic Building Blocks

Oxygen Compounds

Benzene series

Fused Ring Systems

Organic Building Blocks

Oxygen Compounds

Phenols