1-OLEOYL-2-ACETYL-SN-GLYCEROL Property

Boiling point:

490.0±15.0 °C(Predicted)

Density 

0.980±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

ethanol: 20 mg/mL

form 

oil

pka

13.89±0.10(Predicted)

color 

yellow

BRN 

8168731

Stability:

Temperature Sensitive. This compound can rearrange to the 1,3-isomer in solution or during prolonged storage.

CAS DataBase Reference

86390-77-4(CAS DataBase Reference)

Safety

WGK Germany 

3

F 

10-23

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

1-OLEOYL-2-ACETYL-SN-GLYCEROL Chemical Properties,Usage,Production

Chemical Properties

Colourless to light yellow oil

Uses

Activator of phospholipid-dependent protein kinase C; and stimulator of secretion and aggregation in blood platelets.x

Uses

18:1-2:0 DG (1-oleoyl-2-acetyl-sn-glycerol) has been used as a diacyl glycerol (DAG) analog to test its impact on DAG-sensitive channels in thalamocortical (TC) neurons. It may be used as an internal standard for retention time calibration in ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF MS)?for blood sample lipid quantification. It may also be used as a protein kinase C (PKC) activator in adrenal glands.

Definition

ChEBI: 1-Oleoyl-2-acetyl-sn-glycerol is a 1,2-diglyceride.

General Description

18:1-2:0 DG, also called 1-oleoyl-2-acetyl-sn-glycerol (OADG), is a synthetic analog of diacyl glycerol (DAG) and is membrane permeable.

Biochem/physiol Actions

1-Oleoyl-2-acetyl-sn-glycerol is a synthetic, cell permeable diacylglycerol analog. It is often used as an activator of calcium-dependent protein kinase C (PKC).