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mavatrep

Product Name
mavatrep
CAS No.
956274-94-5
Chemical Name
mavatrep
Synonyms
CS-1660;mavatrep;Mavatrep(JNJ-39439335);JNJ 39439335;JNJ39439335;(trans)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzimidazol-5-yl}phenyl)propan-2-ol;Benzenemethanol, α,α-dimethyl-2-[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1H-benzimidazol-6-yl]-;JNJ39439335,Inhibitor,capsaicin,JNJ 39439335,TRP Channel,neuropathic pain,calcium ions,Mavatrep,inhibit,Transient receptor potential channels,hTRPV1 channel,HEK293
CBNumber
CB33040790
Molecular Formula
C25H21F3N2O
Formula Weight
422.45
MOL File
956274-94-5.mol
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mavatrep Property

Boiling point:
612.1±65.0 °C(Predicted)
Density 
1.300±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
10.73±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-4591
Product name
Mavatrep
Purity
99.85%
Packaging
5mg
Price
$420
Updated
2021/12/16
ApexBio Technology
Product number
B5930
Product name
mavatrep
Packaging
5mg
Price
$551
Updated
2021/12/16
ChemScene
Product number
CS-4591
Product name
Mavatrep
Purity
99.85%
Packaging
10mg
Price
$600
Updated
2021/12/16
ApexBio Technology
Product number
B5930
Product name
mavatrep
Packaging
10mg
Price
$788
Updated
2021/12/16
ChemScene
Product number
CS-4591
Product name
Mavatrep
Purity
99.85%
Packaging
50mg
Price
$1800
Updated
2021/12/16
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mavatrep Chemical Properties,Usage,Production

Biological Activity

mavatrep is a potent and orally bioavailable antagonist of trpv1 with ic50 value of 4.6 nm [1][2].transient receptor potential vanilloid-1 (trpv1) is a thermosensitive and nonselective cation channel, and is a member of the trp channel superfamily. the channel is activated by acidic ph (<6.8), thermal stimuli (>43℃), and endogenous lipidic mediators (anandamide and oxidative metabolites of linoleic acid) [1].mavatrep is a potent and orally bioavailable trpv1 antagonist. in hek293 cells that stably express human or rat trpv1 (rtrpv1) channels, mavatrep (1 μm) inhibited capsaicin-induced ca2+ influx with ic50 values of 4.6 nm and 21 nm. in whole-cell patch clamp electrophysiology assay, mavatrep concentration-dependently inhibited the activation of htrpv1 channels by ph (5.0) and capsaicin (1 μm) with ic50 values of 6.8 and 23 nm, respectively. mavatrep (0.1 μm) also inhibited 74 ± 8.1% heat-evoked currents mediated by htrpv1 [1].in the cfa model of inflammatory of pain, mavatrep (10 mg/kg po) significantly reversed cfa-induced thermal hypersensitivity with ed50 and ed80 values of 1.8 and 7.8 mg/kg, respectively [1].

References

[1]. parsons wh, calvo rr, cheung w, et al. benzo[d]imidazole transient receptor potential vanilloid 1 antagonists for the treatment of pain: discovery of trans-2-(2-{2-[2-(4-trifluoromethyl-phenyl)-vinyl]-1h-benzimidazol-5-yl}-phenyl)-propan-2-ol (mavatrep). j med chem, 2015, 58(9): 3859-3874.

mavatrep Preparation Products And Raw materials

Raw materials

Preparation Products

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mavatrep Suppliers

Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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info@chemexpress.com
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
Email
sales@medchemexpress.cn
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United States
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Finetech Industry Limited
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027-87465837 19945049750
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027-8777-2287
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sales@finetechnology-ind.com
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China
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HangZhou YuHao Chemical Technology Co., Ltd.
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0571-82693216
Fax
0571-82880190
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info@yuhaochemical.com
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China
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2031
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696,15000506266 15000506266
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+86-21-52996696
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China
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D&C Chemicals
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+86-21-58447131
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+86-21-61642470
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1724405207@qq.com
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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131981
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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United States
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4662
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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China
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9730
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58
Finetech Industry Limited
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+86-27-87465837 +8618971612321
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86 27 87772287
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info@finetechnology-ind.com
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China
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956274-94-5, mavatrepRelated Search:


  • mavatrep
  • Mavatrep(JNJ-39439335)
  • JNJ 39439335;JNJ39439335
  • (trans)-2-(2-{2-[2-(4-trifluoromethylphenyl)vinyl]-1H-benzimidazol-5-yl}phenyl)propan-2-ol
  • CS-1660
  • Benzenemethanol, α,α-dimethyl-2-[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1H-benzimidazol-6-yl]-
  • JNJ39439335,Inhibitor,capsaicin,JNJ 39439335,TRP Channel,neuropathic pain,calcium ions,Mavatrep,inhibit,Transient receptor potential channels,hTRPV1 channel,HEK293
  • 956274-94-5