ChemicalBook > CAS DataBase List > BHPI
BHPI
- Product Name
- BHPI
- CAS No.
- 56632-39-4
- Chemical Name
- BHPI
- Synonyms
- BHPI;CS-2134;1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-
- CBNumber
- CB33041388
- Molecular Formula
- C21H17NO3
- Formula Weight
- 331.36
- MOL File
- 56632-39-4.mol
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BHPI Property
- Melting point:
- 272-274 °C
- Boiling point:
- 557.7±50.0 °C(Predicted)
- Density
- 1.320±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 5 mg/ml; DMSO: 11 mg/ml; Ethanol: 14 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
- form
- A crystalline solid
- pka
- 9.43±0.30(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 17750
- Product name
- BHPI
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $57
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17750
- Product name
- BHPI
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $100
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17750
- Product name
- BHPI
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $412
- Updated
- 2024/03/01
Tocris
- Product number
- 6116
- Product name
- BHPI
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $745
- Updated
- 2021/12/16
Tocris
- Product number
- 6116
- Product name
- BHPI
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $177
- Updated
- 2021/12/16
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BHPI Chemical Properties,Usage,Production
Description
BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial, and ovarian cancer cell lines at concentrations ranging from 10 to 1,000 nM. It is effective in vivo, driving tumor regression in mice bearing MCF-7 xenografts at a dose of 15 mg/kg daily. BHPI specifically inhibits ERα-dependent gene expression and protein synthesis by activating the unfolded protein response in cells.
Uses
BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial and ovarian cancer cell lines.
storage
Store at -20°C
BHPI Preparation Products And Raw materials
Raw materials
Preparation Products
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BHPI Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77