BHPI

Product Name: BHPI
CAS No.: 56632-39-4
Chemical Name: BHPI
Synonyms: BHPI;CS-2134;1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one;2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-
CBNumber: CB33041388
Molecular Formula: C21H17NO3
Formula Weight: 331.36
MOL File: 56632-39-4.mol

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BHPI Property

Melting point:: 272-274 °C
Boiling point:: 557.7±50.0 °C(Predicted)
Density: 1.320±0.06 g/cm3(Predicted)
solubility: DMF: 5 mg/ml; DMSO: 11 mg/ml; Ethanol: 14 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form: A crystalline solid
pka: 9.43±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17750
Product name: BHPI
Purity: ≥95%
Packaging: 500μg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 17750
Product name: BHPI
Purity: ≥95%
Packaging: 1mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 17750
Product name: BHPI
Purity: ≥95%
Packaging: 5mg
Price: $412
Updated: 2024/03/01

Tocris

Product number: 6116
Product name: BHPI
Purity: ≥98%(HPLC)
Packaging: 50
Price: $745
Updated: 2021/12/16

Tocris

Product number: 6116
Product name: BHPI
Purity: ≥98%(HPLC)
Packaging: 10
Price: $177
Updated: 2021/12/16

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BHPI Chemical Properties,Usage,Production

Description

BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial, and ovarian cancer cell lines at concentrations ranging from 10 to 1,000 nM. It is effective in vivo, driving tumor regression in mice bearing MCF-7 xenografts at a dose of 15 mg/kg daily. BHPI specifically inhibits ERα-dependent gene expression and protein synthesis by activating the unfolded protein response in cells.

Uses

BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial and ovarian cancer cell lines.

storage

Store at -20°C

BHPI Preparation Products And Raw materials

Raw materials

Preparation Products

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BHPI Suppliers

China 41 United Kingdom 1 United States 10 Global 52

Musechem

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TargetMol Chemicals Inc.

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Cckinase, Inc.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Aladdin Scientific

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BOC Sciences

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Cayman Chemical Company

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United States Biological

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MedChemExpress

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56632-39-4, BHPIRelated Search:

BHPI

2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-

1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one

CS-2134

56632-39-4