SPDB

Product Name: SPDB
CAS No.: 115088-06-7
Chemical Name: SPDB
Synonyms: LKB;SPDB;C4-SPDB;SPDB crosslinker;SPDB, 10 mM in DMSO;N-Succinimidyl-4-(2-pyridyldithio)butanoate;5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)butanoate;2,5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)butanoate;4-(Pyridin-2-yldisulfanyl)butyric acid N-Hydroxysuccinimide ester;inhibit,SPDB,Antibody-drug conjugates linkers,ADC Linkers,Inhibitor
CBNumber: CB33044051
Molecular Formula: C13H14N2O4S2
Formula Weight: 326.39
MOL File: 115088-06-7.mol

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SPDB Property

Melting point:: 47-48 °C
Boiling point:: 480.1±55.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Ethanol:100.0(Max Conc. mg/mL);306.39(Max Conc. mM)
pka: 1.89±0.19(Predicted)
form: <47°C Solid,>48°C Liquid
color: Off-white to light yellow

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Safety

HS Code: 29251900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5677
Product name: SPDB
Purity: 99.30%
Packaging: 10mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-5677
Product name: SPDB
Purity: 99.30%
Packaging: 5mg
Price: $108
Updated: 2021/12/16

ChemScene

Product number: CS-5677
Product name: SPDB
Purity: 99.30%
Packaging: 50mg
Price: $336
Updated: 2021/12/16

ChemScene

Product number: CS-5677
Product name: SPDB
Purity: 99.30%
Packaging: 100mg
Price: $456
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611870
Product name: SPDB
Purity: >98%
Packaging: 100mg
Price: $510
Updated: 2021/12/16

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SPDB Chemical Properties,Usage,Production

Uses

SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs)[1].

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing. Bioconjug Chem, 2015 Nov 18, 26(11):2261-78. DOI:10.1021/acs.bioconjchem.5b00430

SPDB Preparation Products And Raw materials

Raw materials

Preparation Products

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SPDB Suppliers

China 84 United States 9 Global 93

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928;68417696 18306209966;13962195629
Email: linda@highfine.com;minhan.zhao@highfine.com
Country: China
ProdList: 1639
Advantage: 58

Beijing HwrkChemical Technology Co., Ltd

Tel: 89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9416
Advantage: 55

Adamas Reagent, Ltd.

Tel: 400-6009262 15618770481
Fax: 021-64823266
Email: yhx@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5873
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4817
Advantage: 55

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80534353 19917294565
Email: et@chemextension.com
Country: China
ProdList: 3828
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

115088-06-7, SPDBRelated Search:

SPDB

2,5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)butanoate

SPDB crosslinker

5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)butanoate

4-(Pyridin-2-yldisulfanyl)butyric acid N-Hydroxysuccinimide ester

LKB

N-Succinimidyl-4-(2-pyridyldithio)butanoate

Butanoic acid, 4-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester

inhibit,SPDB,Antibody-drug conjugates linkers,ADC Linkers,Inhibitor

C4-SPDB

SPDB, 10 mM in DMSO

115088-06-7