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DEL-22379

Product Name
DEL-22379
CAS No.
181223-80-3
Chemical Name
DEL-22379
Synonyms
CS-2171;DEL-22379;DEL-22379 >=98% (HPLC);DEL22379;DEL 22379;DEL-22379;DEL-22379, 98%, an ERK dimerization inhibitor;N-(3-((5-methoxy-1H-indol-3-yl)methylene)-2-oxoindolin-5-yl)-3-(piperidin-1-yl)propanamide;ERK,Inhibitor,DEL-22379,Extracellular signal regulated kinases,inhibit,DEL 22379,Apoptosis;(E)-N-(3-((5-methoxy-1H-indol-3-yl)methylene)-2-oxoindolin-5-yl)-3-(piperidin-1-yl)propanamide;N-{3-[(5-methoxyindol-3-yl)methylene]-2-oxo(1H-benzo[3,4-d]azolidin-5-yl)}-3-piperidylpropanamide;N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide
CBNumber
CB33049203
Molecular Formula
C26H28N4O3
Formula Weight
444.53
MOL File
181223-80-3.mol
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DEL-22379 Property

Boiling point:
763.9±60.0 °C(Predicted)
Density 
1.313±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
11.84±0.20(Predicted)
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Safety

HS Code 
2933790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1679
Product name
DEL-22379
Purity
≥98% (HPLC)
Packaging
5MG
Price
$108
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1679
Product name
DEL-22379
Purity
≥98% (HPLC)
Packaging
25MG
Price
$348
Updated
2024/03/01
Cayman Chemical
Product number
22433
Product name
DEL-22379
Purity
≥98% (mixture of rotamers)
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
22433
Product name
DEL-22379
Purity
≥98% (mixture of rotamers)
Packaging
10mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
22433
Product name
DEL-22379
Purity
≥98% (mixture of rotamers)
Packaging
25mg
Price
$385
Updated
2024/03/01
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DEL-22379 Chemical Properties,Usage,Production

Definition

ChEBI: DEL-22379 is an oxindole that is 5-amino-oxindole in which the 5-amino group has undergone formal condensation with the carboxy group of 3-(piperidin-1-yl)propanoic acid to give the corresponding carboxamide and in which the hydrogens at position 3 have been replaced by a (5-methoxy-1H-indol-3-yl)methylene group (Z configuration). It is an inhibitor of extracellular signal-regulated kinase (ERK) dimerisation. It has a role as an ERK dimerisation inhibitor and an antineoplastic agent. It is a member of piperidines, a member of oxindoles, an enamide and a secondary carboxamide.

Biological Activity

del-22379 is an inhibitor of the dimerization of erk with ic50 values ranging from 150-400 nm regardless of genotypes in oncogenic cells [1].as an spatial regulator of erk signals, erk dimerization is essential. impeding erk dimerization can result in the impeding of erk signals’ extranuclear component and hence result in curtailing tumor development and cellular transformation [1].in hek293 cells, del-22379 abolished egf-stimulated erk dimerization. in these cells, the egf-induced co-immunoprecipitation of hemagglutinin- or flag epitopes- tagged ectopic erk2 molecules, was abolished by del-22379 with an ic50 value of ~0.5 μm. in both assays, the inhibition of del-22379 to erk dimerization was not associated with erk phosphorylation. in the cytoplasm of egf-stimulated hela cells, erk dimerization was prominent, but previous treatment with del-22379 also resulted in no detected erk dimmers [1].in nude mice with some of the aforementioned tumor cell lines, del-22379 at a dose of 15 mg/kg inhibited erk dimerization evidently in xenografted tumors and in liver extracts. del-22379 inhibited the tumor progression of a375 cells (braf mutant) markedly. activated-ras-driven tumors were very sensitive to del-22379. data indicated that tumorigenesis had greater requirements for erk dimerization than for proliferation. in tumors, treatment with del-22379 resulted in extensive mucinous differentiation and cell death [1].

storage

Store at -20°C

References

[1]. herrero a, pinto a, colón-bolea p, et al. small molecule inhibition of erk dimerization prevents tumorigenesis by ras-erk pathway oncogenes. cancer cell, 2015, 28(2): 170-182.

DEL-22379 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DEL-22379 manufacturers

Career Henan Chemical Co
Product
DEL-22379 181223-80-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-02

181223-80-3, DEL-22379Related Search:


  • DEL-22379
  • N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide
  • N-(3-((5-methoxy-1H-indol-3-yl)methylene)-2-oxoindolin-5-yl)-3-(piperidin-1-yl)propanamide
  • DEL-22379, 98%, an ERK dimerization inhibitor
  • N-{3-[(5-methoxyindol-3-yl)methylene]-2-oxo(1H-benzo[3,4-d]azolidin-5-yl)}-3-piperidylpropanamide
  • CS-2171
  • DEL22379;DEL 22379;DEL-22379
  • (E)-N-(3-((5-methoxy-1H-indol-3-yl)methylene)-2-oxoindolin-5-yl)-3-(piperidin-1-yl)propanamide
  • 1-Piperidinepropanamide, N-[2,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-
  • DEL-22379 >=98% (HPLC)
  • ERK,Inhibitor,DEL-22379,Extracellular signal regulated kinases,inhibit,DEL 22379,Apoptosis
  • 181223-80-3