Methylamino-PEG4-acid

Product Name: Methylamino-PEG4-acid
CAS No.: 1283658-71-8
Chemical Name: Methylamino-PEG4-acid
Synonyms: CAS_1283658-71-8;Methylamino-PEG4-acid;Methylamino-PEG4-CH2CH2COOH;Methylamino-PEG4-acid HCl salt;4,7,10,13-Tetraoxa-16-azaheptadecanoic acid
CBNumber: CB33054281
Molecular Formula: C12H25NO6
Formula Weight: 279.33
MOL File: 1283658-71-8.mol

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Methylamino-PEG4-acid Property

Boiling point:: 405.5±40.0 °C(Predicted)
Density: 1.093±0.06 g/cm3(Predicted)
solubility: Soluble in Water, DMSO
pka: 4.28±0.10(Predicted)
form: Viscous Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M563190
Product name: Methylamino-PEG4-acid
Packaging: 2.5mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M563190
Product name: Methylamino-PEG4-acid
Packaging: 5mg
Price: $65
Updated: 2021/12/16

BroadPharm

Product number: BP-22202
Product name: Methylamino-PEG4-acidHClsalt
Purity: 98%
Packaging: 100mg
Price: $320
Updated: 2021/12/16

BroadPharm

Product number: BP-22202
Product name: Methylamino-PEG4-acidHClsalt
Purity: 98%
Packaging: 250mg
Price: $540
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1537
Product name: Methylamino-PEG4-acid
Packaging: 100mg
Price: $623
Updated: 2021/12/16

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Methylamino-PEG4-acid Chemical Properties,Usage,Production

Description

Methylamino-PEG4-acid HCl salt is a PEG linker containing a carboxylic acid with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Methylamino-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Methylamino-PEG4-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Methylamino-PEG4-acid Suppliers

China 26 United Kingdom 1 United States 3 Global 30

Borenpharm Co., Ltd

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SHANGHAI FDC-CHEMICAL CO.,LTD

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Jiangsu aikang biomedical research and development co., LTD

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Country: China
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TargetMol Chemicals Inc.

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Wuhan Borenpharm Co., Ltd

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Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

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Shaanxi borno biotechnology co., LTD

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Zhengzhou anmousse chemical products co. LTD

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1283658-71-8, Methylamino-PEG4-acidRelated Search:

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Methylamino-PEG4-acid HCl salt

CAS_1283658-71-8

4,7,10,13-Tetraoxa-16-azaheptadecanoic acid

Methylamino-PEG4-CH2CH2COOH

1283658-71-8