Azido-PEG1-PFP ester

Product Name: Azido-PEG1-PFP ester
CAS No.: 1807505-32-3
Chemical Name: Azido-PEG1-PFP ester
Synonyms: Azido-PEG1-PFP ester;N3-PEG1-CH2CH2COOPFP;perfluorophenyl 3-(2-azidoethoxy)propanoate;Pentafluorophenyl 3-(2-azidoethoxy)propanoate;(2,3,4,5,6-pentafluorophenyl) 3-(2-azidoethoxy)propanoate;Perfluorophenyl 3-(2-azidoethoxy)propanoate , Azido-PEG1-PFP ester
CBNumber: CB33062341
Molecular Formula: C11H8F5N3O3
Formula Weight: 325.2
MOL File: 1807505-32-3.mol

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Azido-PEG1-PFP ester Property

solubility: Soluble in DMSO, DCM, DMF

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-21861
Product name: Azido-PEG1-PFPester
Purity: 98%
Packaging: 100mg
Price: $260
Updated: 2021/12/16

BroadPharm

Product number: BP-21861
Product name: Azido-PEG1-PFPester
Purity: 98%
Packaging: 250mg
Price: $460
Updated: 2021/12/16

BroadPharm

Product number: BP-21861
Product name: Azido-PEG1-PFPester
Purity: 98%
Packaging: 1g
Price: $950
Updated: 2021/12/16

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Azido-PEG1-PFP ester Chemical Properties,Usage,Production

Description

Azido-PEG1-PFP ester is a click chemistry PEG linker containing azide and PFP ester moities. The azide can participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form triazole groups. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester.

Uses

Azido-PEG1-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azido-PEG1-PFP ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Azido-PEG1-PFP ester Suppliers

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1807505-32-3, Azido-PEG1-PFP esterRelated Search:

Perfluorophenyl 3-(2-(4-formylbenzamido)ethoxy)propanoate Mal-PEG1-PFP N3-PEG7-OH Azido-PEG12-acid N3-PEG12-CH2CH2COOH N3-PEG6-CH2COOH Azido-PEG12-NHS ester Azido-PEG12-NHS ester Azido-PEG5-acid Azido-PEG1-acid

Azido-PEG1-PFP ester

(2,3,4,5,6-pentafluorophenyl) 3-(2-azidoethoxy)propanoate

perfluorophenyl 3-(2-azidoethoxy)propanoate

Pentafluorophenyl 3-(2-azidoethoxy)propanoate

N3-PEG1-CH2CH2COOPFP

Perfluorophenyl 3-(2-azidoethoxy)propanoate , Azido-PEG1-PFP ester

1807505-32-3

C11H8F5N3O3