Benzyl-PEG2-CH2CO2tBu
- Product Name
- Benzyl-PEG2-CH2CO2tBu
- CAS No.
- 1309451-06-6
- Chemical Name
- Benzyl-PEG2-CH2CO2tBu
- Synonyms
- tert-butyl 2-(2-(benzyloxy)ethoxy)acetate;BnO-PEG1-CH2CO2tBu;Benzyl-PEG2-CH2CO2tBu;Bromoacetamido-PEG3-amine-Boc;tert-butyl 2-(2-(benzyloxy)ethoxy)acetate(WXPC0080);Acetic acid, 2-[2-(phenylmethoxy)ethoxy]-, 1,1-dimethylethyl ester
- CBNumber
- CB33062376
- Molecular Formula
- C15H22O4
- Formula Weight
- 266.33
- MOL File
- 1309451-06-6.mol
Benzyl-PEG2-CH2CO2tBu Property
- Boiling point:
- 354.2±22.0 °C(Predicted)
- Density
- 1.048±0.06 g/cm3(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B289365
- Product name
- Benzyl-Peg2-Ch2co2tbu
- Packaging
- 50mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- BIPG1190
- Product name
- Benzyl-PEG2-CH2CO2tBu
- Packaging
- 500mg
- Price
- $740
- Updated
- 2021/12/16
- Product number
- BP-22150
- Product name
- Benzyl-PEG2-CH2CO2tBu
- Purity
- 98%
- Packaging
- 2g
- Price
- $840
- Updated
- 2021/12/16
Benzyl-PEG2-CH2CO2tBu Chemical Properties,Usage,Production
Description
Benzyl-PEG2-CH2CO2tBu is a PEG linker containing a benzyl group and a t-butyl protected carbonyl. Both the benzyl and t-Butyl group can be removed under acidic conditions. The carboxylic acid can be reacted with primary amines in the presence of activators such as EDC and DCC to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.
Uses
BnO-PEG1-CH2CO2tBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Benzyl-PEG2-CH2CO2tBu Preparation Products And Raw materials
Raw materials
Preparation Products
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