Bis-Propargyl-PEG13

Product Name: Bis-Propargyl-PEG13
CAS No.: 1351373-50-6
Chemical Name: Bis-Propargyl-PEG13
Synonyms: CAS_1351373-50-6;Bis-propargyl-PEG12;Bis-Propargyl-PEG13;Propargyl-PEG12-Propargyl;4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne;Bis-propargyl-PEG12/4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne
CBNumber: CB33062422
Molecular Formula: C30H54O13
Formula Weight: 622.74
MOL File: 1351373-50-6.mol

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Bis-Propargyl-PEG13 Property

solubility: Soluble in Water, DMSO, DMF, DCM

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B523918
Product name: Bis-propargyl-PEG13
Packaging: 5mg
Price: $45
Updated: 2021/12/16

BroadPharm

Product number: BP-22514
Product name: Bis-propargyl-PEG13
Purity: 98%
Packaging: 250mg
Price: $350
Updated: 2021/12/16

Activate Scientific

Product number: AS107811
Product name: Bis-propargyl-PEG12
Purity: 97%
Packaging: 250mg
Price: $435
Updated: 2021/12/16

BroadPharm

Product number: BP-22514
Product name: Bis-propargyl-PEG13
Purity: 98%
Packaging: 500mg
Price: $540
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1305
Product name: Bis-Propargyl-PEG13
Packaging: 250mg
Price: $681
Updated: 2021/12/16

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Bis-Propargyl-PEG13 Chemical Properties,Usage,Production

Description

Bis-propargyl-PEG13 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Uses

Bis-propargyl-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bis-propargyl-PEG12 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

IC 50

PEGs

structure and hydrogen bonding

Bis-propargyl-PEG13 comprises two propargyl groups which can form triazole linkages with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The hydrophilic PEG units help improve the solubility of the molecule in aqueous media.

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bis-Propargyl-PEG13 Preparation Products And Raw materials

Raw materials

Preparation Products

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Bis-Propargyl-PEG13 Suppliers

China 32 United Kingdom 1 United States 3 Global 36

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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1351373-50-6, Bis-Propargyl-PEG13Related Search:

Bis-propargyl-PEG14 Bis-Propargyl-PEG7 Bis-propargyl-PEG11 Bis-propargyl-PEG16 Bis-Propargyl-PEG10

Bis-Propargyl-PEG13

Bis-propargyl-PEG12

CAS_1351373-50-6

4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne

Bis-propargyl-PEG12/4,7,10,13,16,19,22,25,28,31,34,37,40-Tridecaoxatritetraconta-1,42-diyne

Propargyl-PEG12-Propargyl

1351373-50-6

C30H54O13