Cbz-N-amido-PEG8-acid
- Product Name
- Cbz-N-amido-PEG8-acid
- CAS No.
- 1334177-87-5
- Chemical Name
- Cbz-N-amido-PEG8-acid
- Synonyms
- CBZ-NH-PEG8-COOH;CBZ-NH-PEG8-acid;CbzNH-PEG8-C2-COOH;Cbz-NH-PEG8-C2-acid;Cbz-N-amido-PEG8-acid;CBZ-N-AMIDO-PEG8-COOH;CBZ-NH-PEG8-CH2CH2COOH;CBZ-NH-PEG8-propionic acid;CBZ-N-amido-dPEG??-acid (QBD-10276);1-(Benzyl) 5,8,11,14,17,20,23,26-octaoxa-2-azanonacosanedioate
- CBNumber
- CB33062462
- Molecular Formula
- C27H45NO12
- Formula Weight
- 575.65
- MOL File
- 1334177-87-5.mol
Cbz-N-amido-PEG8-acid Property
- Boiling point:
- 681.2±55.0 °C(Predicted)
- Density
- 1.165±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in Water, DMSO, DCM, DMF
- pka
- 4.28±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C227215
- Product name
- Cbz-NH-PEG8-CH2CH2COOH
- Packaging
- 100mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- POL0002313
- Product name
- Z-NH-DPEG-(8)-COOH
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $302.4
- Updated
- 2021/12/16
- Product number
- PEG1800
- Product name
- Z-NH-dPEG(8)-COOH
- Packaging
- 100mg
- Price
- $351
- Updated
- 2021/12/16
- Product number
- 10276
- Product name
- CBZ-N-amido-dPEG®₈-acid
- Packaging
- 1000mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- BP-21647
- Product name
- Cbz-N-amido-PEG8-acid
- Purity
- 98%
- Packaging
- 2g
- Price
- $720
- Updated
- 2021/12/16
Cbz-N-amido-PEG8-acid Chemical Properties,Usage,Production
Description
Cbz-N-amido-PEG8-acid is a PEG linker containing a CBZ-protected amino group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The protected amine can be deprotected by acidic conditions.
Uses
Cbz-NH-PEG8-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Cbz-N-amido-PEG8-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Cbz-N-amido-PEG8-acid Suppliers
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View Lastest Price from Cbz-N-amido-PEG8-acid manufacturers
- Product
- CBZ-NH-PEG8-CH2CH2COOH 1334177-87-5
- Price
- US $510.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2025-11-19
- Product
- 3-oxo-1-phenyl-2,7,10,13,16,19,22,25,28-nonaoxa-4-azahentriacontan-31-oic acid 1334177-87-5
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2025-09-12