THP-SS-PEG1-Tos

Product Name: THP-SS-PEG1-Tos
CAS No.: 1807512-37-3
Chemical Name: THP-SS-PEG1-Tos
Synonyms: THP-SS-PEG1-Tos;2-((2-((Tetrahydro-2H-pyran-2-yl)oxy)ethyl)disulfaneyl)ethyl 4-methylbenzenesulfonate;Ethanol, 2-[[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]dithio]-, 1-(4-methylbenzenesulfonate)
CBNumber: CB33062684
Molecular Formula: C16H24O5S3
Formula Weight: 392.55
MOL File: 1807512-37-3.mol

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THP-SS-PEG1-Tos Property

Boiling point:: 539.4±50.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22778
Product name: THP-SS-PEG1-Tos
Purity: 98%
Packaging: 100mg
Price: $220
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1855
Product name: THP-SS-PEG1-Tos
Packaging: 100mg
Price: $428
Updated: 2021/12/16

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THP-SS-PEG1-Tos Chemical Properties,Usage,Production

Description

THP-SS-PEG1-Tos is a cleavable linker containing a THP protecting group and a tosyl end group. Tos is a good leaving group by reacting with nucleophiles, The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent.

Uses

THP-SS-PEG1-Tos is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

THP-SS-PEG1-Tos Preparation Products And Raw materials

Raw materials

Preparation Products

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THP-SS-PEG1-Tos Suppliers

China 17 United Kingdom 1 United States 3 Global 21

Bide Pharmatech Ltd.

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Jinan elephant international trading co., LTD

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Beijing Jin Ming Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Hangzhou Huarong Pharm Co., Ltd.

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Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

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Zhengzhou Akem Chemical Co., Ltd

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Shanghai Huici Pharmaceutical Technology Co., LTD

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Affinity（Wuhan）Ltd.

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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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1807512-37-3, THP-SS-PEG1-TosRelated Search:

THP-SS-alcohol THP-PEG3 THP-PEG8-Tos TETRAHYDROPYRANYLDIETHYLENEGLYCOL THP-PEG4 2-(TETRAHYDRO-2H-PYRAN-2-YLOXY)ETHANOL THP-SS-PEG1-t-butyl ester

THP-SS-PEG1-Tos

Ethanol, 2-[[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]dithio]-, 1-(4-methylbenzenesulfonate)

2-((2-((Tetrahydro-2H-pyran-2-yl)oxy)ethyl)disulfaneyl)ethyl 4-methylbenzenesulfonate

1807512-37-3

C16H24O5S3