THP-SS-alcohol

Product Name: THP-SS-alcohol
CAS No.: 877864-04-5
Chemical Name: THP-SS-alcohol
Synonyms: THP-SS-alcohol;Ethanol, 2-[[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]dithio]-;2-((2-((Tetrahydro-2H-pyran-2-yl)oxy)ethyl)disulfaneyl)ethan-1-ol
CBNumber: CB73062682
Molecular Formula: C9H18O3S2
Formula Weight: 238.37
MOL File: 877864-04-5.mol

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22627
Product name: THP-SS-alcohol
Purity: 98%
Packaging: 500mg
Price: $220
Updated: 2021/12/16

BroadPharm

Product number: BP-22627
Product name: THP-SS-alcohol
Purity: 98%
Packaging: 5G
Price: $780
Updated: 2021/12/16

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THP-SS-alcohol Chemical Properties,Usage,Production

Description

THP-SS-alcohol is a cleavable linker contains a THP alcohol protecting group and a disulfide bond. The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent. The THP protecting group can be removed under acidic conditions.

Uses

THP-SS-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Disulfide Cleavable Linker; Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

THP-SS-alcohol Preparation Products And Raw materials

Raw materials

Preparation Products

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THP-SS-alcohol Suppliers

China 20 United States 2 Global 22

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877864-04-5, THP-SS-alcoholRelated Search:

THP-PEG3 THP-PEG8-Tos TETRAHYDROPYRANYLDIETHYLENEGLYCOL THP-PEG4 THP-SS-PEG1-Tos 2-(TETRAHYDRO-2H-PYRAN-2-YLOXY)ETHANOL THP-SS-PEG1-t-butyl ester

THP-SS-alcohol

Ethanol, 2-[[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]dithio]-

2-((2-((Tetrahydro-2H-pyran-2-yl)oxy)ethyl)disulfaneyl)ethan-1-ol

877864-04-5