CCT251545

Product Name: CCT251545
CAS No.: 1661839-45-7
Chemical Name: CCT251545
Synonyms: CS-2537;CCT251545;LM-3773,CCT251545;CCT-251545;CCT 251545;inhibit,Wnt,CCT251545,Inhibitor,CCT-251545,CCT 251545;8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one;8-[3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one;2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-
CBNumber: CB33067003
Molecular Formula: C23H24ClN5O
Formula Weight: 421.92
MOL File: 1661839-45-7.mol

More

Less

CCT251545 Property

Boiling point:: 709.7±60.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: ≥42.2 mg/mL in DMSO; insoluble in H2O; ≥2.33 mg/mL in EtOH with ultrasonic
form: solid
pka: 15.81±0.20(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 18761
Product name: CCT251545
Purity: ≥95%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 18761
Product name: CCT251545
Purity: ≥95%
Packaging: 5mg
Price: $190
Updated: 2024/03/01

Cayman Chemical

Product number: 18761
Product name: CCT251545
Purity: ≥95%
Packaging: 10mg
Price: $333
Updated: 2024/03/01

TRC

Product number: C227973
Product name: CCT251545
Packaging: 1mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-5359
Product name: CCT251545
Purity: 99.27%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

More

Less

CCT251545 Chemical Properties,Usage,Production

Description

CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC₅₀ = 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression. It reduces tumor growth in COLO 205 human colon cancer xenografts after oral dosing (70 mg/kg bid) and in Wnt-dependent tumors.

Uses

CCT251545 is a potent inhibitor of WNT signaling with good oral pharmacokinetics.

Definition

ChEBI: CCT251545 is a chloropyridine that is 3-chloropyridine substituted by a 1-oxo-2,8-diazaspiro[4.5]decan-8-yl group and a 4-(1-methyl-1H-pyrazol-4-yl)phenyl group at positions 4 and 5, respectively. It is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM) and a potent and selective chemical probe for cyclin-dependent kinases CDK8 and CDK19. It has a role as a Wnt signalling inhibitor, an antineoplastic agent and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a chloropyridine, a member of pyrazoles and an azaspiro compound.

References

[1]. mallinger a, crumpler s, pichowicz m, et al. discovery of potent, orally bioavailable, small-molecule inhibitors of wnt signaling from a cell-based pathway screen. j med chem, 2015, 58(4): 1717-1735.
[2]. dale t, clarke pa, esdar c, et al. a selective chemical probe for exploring the role of cdk8 and cdk19 in human disease. nat chem biol, 2015, 11(12): 973-980.

CCT251545 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CCT251545 Suppliers

China 60 United States 9 Global 69

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52927
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

1661839-45-7, CCT251545Related Search:

1-tert-butyl 4-methyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate 3-BroMo-4,5-dichloropyridine 8-(3-bromo-5-chloropyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one 1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrazole 4-(4-CHLOROPHENYL)-1-METHYL-1H-PYRAZOLE

CCT251545

8-[3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one

LM-3773,CCT251545

8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

CS-2537

CCT-251545;CCT 251545

2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-

inhibit,Wnt,CCT251545,Inhibitor,CCT-251545,CCT 251545

1661839-45-7

1661839-45-1

C23H24ClN5O