PCNA-I1

ChemicalBook > CAS DataBase List > PCNA-I1

Product Name: PCNA-I1
CAS No.: 444930-42-1
Chemical Name: PCNA-I1
Synonyms: PCNA-I1,PCNA-I-1,DNA/RNA Synthesis,inhibit,PCNAI1,Inhibitor,PCNA I1;N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide;N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide;2-Thiophenecarboxylic acid, 3-methyl-, 2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide;N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
CBNumber: CB33067568
Molecular Formula: C17H14N2O2S
Formula Weight: 310.37
MOL File: 444930-42-1.mol

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PCNA-I1 Property

Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form: A crystalline solid
pka: 8.31±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20454
Product name: PCNA-I1
Purity: ≥98%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 20454
Product name: PCNA-I1
Purity: ≥98%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 20454
Product name: PCNA-I1
Purity: ≥98%
Packaging: 25mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 20454
Product name: PCNA-I1
Purity: ≥98%
Packaging: 50mg
Price: $535
Updated: 2024/03/01

AK Scientific

Product number: 2656EM
Product name: Pcna-I1
Packaging: 10mg
Price: $241
Updated: 2021/12/16

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PCNA-I1 Chemical Properties,Usage,Production

Description

PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (K_d = 0.41 μM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC₅₀s = 0.05-0.3 μM) over non-transformed cells (IC₅₀s = 0.99-2 μM). PCNA-I1 leads to an accumulation of cells in the G₁ phase during the first 24 hours of incubation and halts the cell cycle in the S and G₂/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.

PCNA-I1 Preparation Products And Raw materials

Raw materials

Preparation Products

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444930-42-1, PCNA-I1Related Search:

N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide

2-Thiophenecarboxylic acid, 3-methyl-, 2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide

PCNA-I1,PCNA-I-1,DNA/RNA Synthesis,inhibit,PCNAI1,Inhibitor,PCNA I1

N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide

444930-42-1