ChemicalBook > CAS DataBase List > PCNA-I1
PCNA-I1
- Product Name
- PCNA-I1
- CAS No.
- 444930-42-1
- Chemical Name
- PCNA-I1
- Synonyms
- PCNA-I1,PCNA-I-1,DNA/RNA Synthesis,inhibit,PCNAI1,Inhibitor,PCNA I1;N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide;N'-((1-Hydroxynaphthalen-2-yl)methylene)-3-methylthiophene-2-carbohydrazide;2-Thiophenecarboxylic acid, 3-methyl-, 2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide;N-(3-Methylthiophene-2-carboxylic acid)-N'-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide
- CBNumber
- CB33067568
- Molecular Formula
- C17H14N2O2S
- Formula Weight
- 310.37
- MOL File
- 444930-42-1.mol
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PCNA-I1 Property
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
- form
- A crystalline solid
- pka
- 8.31±0.50(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 20454
- Product name
- PCNA-I1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 20454
- Product name
- PCNA-I1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $130
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 20454
- Product name
- PCNA-I1
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $302
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 20454
- Product name
- PCNA-I1
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $535
- Updated
- 2024/03/01
AK Scientific
- Product number
- SYN5080
- Product name
- PCNA-I1
- Packaging
- 50mg
- Price
- $500
- Updated
- 2021/12/16
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PCNA-I1 Chemical Properties,Usage,Production
Description
PCNA-I1 is an inhibitor of proliferating cell nuclear antigen (PCNA) that binds to PCNA trimers (Kd = 0.41 μM) and dose-dependently reduces the level of PCNA associated with chromatin in PC3 cells. It preferentially inhibits growth of a variety of human and mouse cancer cell lines (IC50s = 0.05-0.3 μM) over non-transformed cells (IC50s = 0.99-2 μM). PCNA-I1 leads to an accumulation of cells in the G1 phase during the first 24 hours of incubation and halts the cell cycle in the S and G2/M phases by 72 hours following treatment. It also reduces tumor growth in an LNCaP prostate cancer mouse xenograft model when administered at a dose of 10 mg/kg, five days per week, for two weeks.
PCNA-I1 Preparation Products And Raw materials
Raw materials
Preparation Products
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