ChemicalBook > CAS DataBase List > UNC2170 Maleate

UNC2170 Maleate

Product Name
UNC2170 Maleate
CAS No.
1648707-58-7
Chemical Name
UNC2170 Maleate
Synonyms
UNC-2170;UNC-2170 HCl;UNC2170 Maleate;UNC2170 trifluoroacetate;3-Bromo-N-(3-(tert-butylamino)propyl)benzamide;Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-;UNC-2170,UNC2170,Kme readers,tudor domain,UNC 2170,H4K20me2,ligand,53BP1,inhibit,double-strand DNA breaks,Inhibitor
CBNumber
CB33067588
Molecular Formula
C14H21BrN2O
Formula Weight
313.23
MOL File
1648707-58-7.mol
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UNC2170 Maleate Property

Boiling point:
419.6±30.0 °C(Predicted)
Density 
1.233±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml).
form 
solid
pka
14.63±0.46(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17374
Product name
UNC2170 (maleate)
Purity
≥95%
Packaging
1mg
Price
$42
Updated
2022/04/27
Cayman Chemical
Product number
17374
Product name
UNC2170 (maleate)
Purity
≥95%
Packaging
5mg
Price
$165
Updated
2022/04/27
Cayman Chemical
Product number
17374
Product name
UNC2170 (maleate)
Purity
≥95%
Packaging
10mg
Price
$309
Updated
2022/04/27
Cayman Chemical
Product number
17374
Product name
UNC2170 (maleate)
Purity
≥95%
Packaging
25mg
Price
$668
Updated
2022/04/27
AK Scientific
Product number
SYN5678
Product name
UNC2170maleate
Packaging
50mg
Price
$1052
Updated
2021/12/16
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UNC2170 Maleate Chemical Properties,Usage,Production

Description

UNC-2170 (1648707-58-7), identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1

References

1) Perfetti?et al.?(2015),?Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein 53BP1; ACS Chem. Biol.,?10?1072

UNC2170 Maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC2170 Maleate Suppliers

China 36 United Kingdom 1 United States 3 Global 40
Pharmacodia (Beijing) Co.,Ltd
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1648707-58-7, UNC2170 MaleateRelated Search:

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  • UNC2170 trifluoroacetate
  • UNC2170 Maleate
  • UNC-2170
  • Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-
  • 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide
  • UNC-2170 HCl
  • UNC-2170,UNC2170,Kme readers,tudor domain,UNC 2170,H4K20me2,ligand,53BP1,inhibit,double-strand DNA breaks,Inhibitor
  • 1648707-58-7