2-N-HEXYL-4-PENTYNOIC ACID

Product Name: 2-N-HEXYL-4-PENTYNOIC ACID
CAS No.: 96017-59-3
Chemical Name: 2-N-HEXYL-4-PENTYNOIC ACID
Synonyms: Hexyl-4-pentynoic Acid;2-Hexyl-4-pentynoic Acid;2-PROPARGYLOCTANOIC ACID;2-Hexyl-4-pentynoicAcid>2-N-HEXYL-4-PENTYNOIC ACID;2-(2-PROPYNYL)OCTANOIC ACID;Hexyl-4-pentynoic acid (HPA);R-2-(2-propynyl)octanoic acid;2-(2-Propyn-1-yl)octanoic Acid;2-(Prop-2-yn-1-yl)octanoic acid
CBNumber: CB5317246
Molecular Formula: C11H18O2
Formula Weight: 182.26
MOL File: 96017-59-3.mol

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2-N-HEXYL-4-PENTYNOIC ACID Property

Boiling point:: 287.1±23.0 °C(Predicted)
Density: 0.94
refractive index: 1.4450-1.4510
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka: 4.24±0.21(Predicted)
form: oil
color: Colorless
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2916.19.3000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H0964
Product name: 2-Hexyl-4-pentynoic Acid
Purity: >95.0%(T)
Packaging: 5g
Price: $239
Updated: 2024/03/01

TCI Chemical

Product number: H0964
Product name: 2-Hexyl-4-pentynoic Acid
Purity: >95.0%(T)
Packaging: 25g
Price: $762
Updated: 2024/03/01

Cayman Chemical

Product number: 15205
Product name: 2-hexyl-4-Pentynoic Acid
Purity: ≥95%
Packaging: 1g
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 15205
Product name: 2-hexyl-4-Pentynoic Acid
Purity: ≥95%
Packaging: 5g
Price: $257
Updated: 2024/03/01

Cayman Chemical

Product number: 15205
Product name: 2-hexyl-4-Pentynoic Acid
Purity: ≥95%
Packaging: 250mg
Price: $44
Updated: 2024/03/01

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2-N-HEXYL-4-PENTYNOIC ACID Chemical Properties,Usage,Production

Description

2-hexyl-4-Pentynoic acid is a derivative of valproic acid , an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC₅₀ = 13 μM) than valproic acid (IC₅₀ = 398 μM). 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 μM. It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 μM.

References

1) Eikel et al. (2006), Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives; Chem. Res. Toxicol., 19 272 2) Leng et al. (2010), Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction; Neurosci. Lett., 476 127

2-N-HEXYL-4-PENTYNOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-N-HEXYL-4-PENTYNOIC ACID Suppliers

Americas 1 China 31 Europe 1 Germany 2 India 1 Japan 1 United Kingdom 4 United States 10 Global 51

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96017-59-3, 2-N-HEXYL-4-PENTYNOIC ACIDRelated Search:

ML234 C 646 5-Azacytidine Entinostat N-HEXYLLITHIUM 1,3,4,6-TETRA-O-ACETYL-2-AZIDO-2-DEOXY-ALPHA-D-MANNOPYRANOSE 4-PENTYNOIC ACID Octanoic acid 4-Pentyn-1-ol 4-Fluorocinnamic acid 2-N-HEXYL-4-PENTYNOIC ACID

2-(2-PROPYNYL)OCTANOIC ACID

2-N-HEXYL-4-PENTYNOIC ACID

2-PROPARGYLOCTANOIC ACID

2-Hexyl-4-pentynoic Acid

2-(Prop-2-yn-1-yl)octanoic acid

2-Propargyloctanoic Acid 2-(2-Propynyl)octanoic Acid

Hexyl-4-pentynoic acid (HPA)

R-2-(2-propynyl)octanoic acid

Hexyl-4-pentynoic Acid

2-Hexyl-4-pentynoicAcid&gt

HDAC inhibitor,Heat shock proteins,HSP70,Excitotoxicity,Histone deacetylases,inhibit,HDAC,Neuroprotection,2hexyl4Pentynoic Acid,2 hexyl 4 Pentynoic Acid,Inhibitor,Glutamate,HSP,Valproic acid

Octanoic acid, 2-(2-propyn-1-yl)-

2-(2-Propyn-1-yl)octanoic Acid

96017-59-3

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