4-PENTYNOIC ACID
- Product Name
- 4-PENTYNOIC ACID
- CAS No.
- 6089-09-4
- Chemical Name
- 4-PENTYNOIC ACID
- Synonyms
- Pent-4-yn-1-oic acid;PROPARGYLACETIC ACID;4-PENTYNOIC ACID;pent-4-yn-1-oicacid;4-Pentynoicacid,98%;TIMTEC-BB SBB009121;Pentane-4-ynoic acid;4-Pentynoic acid ,95%;4-Pentynoic acid, 95&percnt:;4-Pentynoic acid, 10 mM in DMSO
- CBNumber
- CB6492458
- Molecular Formula
- C5H6O2
- Formula Weight
- 98.1
- MOL File
- 6089-09-4.mol
4-PENTYNOIC ACID Property
- Melting point:
- 54-57 °C(lit.)
- Boiling point:
- 110 °C30 mm Hg(lit.)
- Density
- 1.1133 (rough estimate)
- refractive index
- 1.3930 (estimate)
- Flash point:
- 75 °C
- storage temp.
- 2-8°C
- pka
- 4.30±0.10(Predicted)
- form
- Crystalline Powder or Flakes
- color
- White to beige
- Water Solubility
- Soluble in low polarity organic solvents. Soluble in water.
- Sensitive
- Light & Air Sensitive & Hygroscopic
- BRN
- 1742047
- InChIKey
- MLBYLEUJXUBIJJ-UHFFFAOYSA-N
- LogP
- 0.402 (est)
- CAS DataBase Reference
- 6089-09-4(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- RTECS
- SC4751000
- F
- 8-10-23
- Hazard Note
- Corrosive
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29161900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 232211
- Product name
- 4-Pentynoic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $67.8
- Updated
- 2025/07/31
- Product number
- 232211
- Product name
- 4-Pentynoic acid
- Purity
- 95%
- Packaging
- 5g
- Price
- $203
- Updated
- 2025/07/31
- Product number
- P2341
- Product name
- 4-Pentynoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- P2341
- Product name
- 4-Pentynoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- P284900
- Product name
- 4-Pentynoic Acid
- Packaging
- 5g
- Price
- $165
- Updated
- 2021/12/16
4-PENTYNOIC ACID Chemical Properties,Usage,Production
Chemical Properties
white to beige crystalline powder or flakes
Uses
4-Pentynoic Acid is a hypoglycemic agent shown to increase liver tyrosine aminotransferase and plasma corticosterone while decreasing blood sugar in rats.
Uses
4-Pentynoic acid was used:
- as building block for the synthesis of library of eight sequence-defined model oligomers
- in one-pot synthesis of the complex polycyclic heterocycles benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinone derivatives
- in the synthesis of various allenenols lactones [5(E)-(2-allenylidene)-tetrahydro-2-furanones]
- in the synthesis of a cyctotoxic macrolide by ring-closing metathesis of a bis acetylene
General Description
4-Pentynoic acid undergoes copper-catalyzed intramolecular cyclizations to form enol lactones. It also reacts with 1-bromo-1-alkynes in the presence of a Pd catalyst to yield biologically active ynenol lactones.
Synthesis
5390-04-5
6089-09-4
General procedure for the synthesis of 4-pentynoic acid from 4-pentyn-1-ol: 4-pentyn-1-ol (1 mL, 10.7 mmol) was dissolved in acetone and the solution was cooled to 0 °C. Jones' reagent was slowly added dropwise under vigorous stirring until the reaction mixture remained orange in color. Subsequently, the reaction mixture was allowed to warm up to room temperature and Jones reagent was continued to be added dropwise to maintain the orange color. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, water was added and extracted several times with ether (Et2O). The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure to give the crude product. Purification by rapid chromatography on silica gel (eluent: hexane/ether=8:2) gave the colorless oily product 4-pentynoic acid in 82% yield.1H NMR (400MHz, CDCl3) δ: 2.61-2.59 (m, 2H), 2.52-2.48 (m, 2H), 1.98-1.95 (m, 1H) ppm.
References
[1] Organic Letters, 2016, vol. 18, # 11, p. 2600 - 2603
[2] Patent: WO2016/128541, 2016, A1. Location in patent: Page/Page column 53
[3] Patent: WO2017/162834, 2017, A1. Location in patent: Page/Page column 45
[4] Tetrahedron, 2009, vol. 65, # 24, p. 4664 - 4670
[5] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 15, p. 2976 - 2979
4-PENTYNOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-PENTYNOIC ACID Suppliers
- Tel
- 021-37910092; 15821801668
- Fax
- 021-37910267
- cong44@126.com
- Country
- China
- ProdList
- 296
- Advantage
- 58
- Tel
- 086-021-15821262312 15821262312
- info@alkynechem.com
- Country
- China
- ProdList
- 1985
- Advantage
- 58
- Tel
- 023-13650506873 19923294409
- xingcanyaoye@sina.com
- Country
- China
- ProdList
- 1604
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 18515581800 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9400
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2809
- Advantage
- 65
View Lastest Price from 4-PENTYNOIC ACID manufacturers
- Product
- 4-Pentynoic acid 6089-09-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%
- Supply Ability
- 200KG
- Release date
- 2018-08-15