DL-PROPARGYLGLYCINE
- Product Name
- DL-PROPARGYLGLYCINE
- CAS No.
- 64165-64-6
- Chemical Name
- DL-PROPARGYLGLYCINE
- Synonyms
- NSC21940;DL-Pra-OH;H-DL-PRA-OH;H-DL-Prg-OH;DL-PROPARGYL-GLY-OH;DL-PROPARGYLGLYCINE;DL-Gly(Propargyl)-OH;H-PROPARGYL-DL-GLY-OH;H-DL-GLY(PROPARGYL)-OH;H-PROPARGYL-DL-GLYCINE
- CBNumber
- CB6140609
- Molecular Formula
- C5H7NO2
- Formula Weight
- 113.11
- MOL File
- 64165-64-6.mol
DL-PROPARGYLGLYCINE Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml).
- form
- Crystalline Powder
- color
- White to off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P7888
- Product name
- DL-Propargylglycine
- Purity
- cystathionine γ-lyase inhibitor
- Packaging
- 1g
- Price
- $226
- Updated
- 2024/03/01
- Product number
- P7888
- Product name
- DL-Propargylglycine
- Purity
- cystathionine γ-lyase inhibitor
- Packaging
- 5g
- Price
- $345.2
- Updated
- 2024/03/01
- Product number
- P7888
- Product name
- DL-Propargylglycine
- Purity
- cystathionine γ-lyase inhibitor
- Packaging
- 250mg
- Price
- $77.4
- Updated
- 2024/03/01
- Product number
- 287837
- Product name
- DL-Propargylglycine
- Packaging
- 500mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- 07081
- Product name
- DL-Propargylglycine,≥98%
- Purity
- ≥98%
- Packaging
- 1G
- Price
- $96.45
- Updated
- 2021/12/16
DL-PROPARGYLGLYCINE Chemical Properties,Usage,Production
Description
Propargylglycine (64165-64-6) is an irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-γ-lyase. It inhibits H2S production in rat liver preparations (IC50=55 μM) and inhibits the rise in plasma H2S in rats with hemorrhagic shock2. Propargylglycine reduces inflammation in a rodent carrageenan-induced hindpaw edema model3 and ameliorates gentamycin-induced nephrotoxicity1.
Chemical Properties
White to off-white powder
Uses
Dl-propargylglycine is an inhibitor of hydrogen sulfide (H2S) production.
Synthesis Reference(s)
Journal of the American Chemical Society, 76, p. 3484, 1954 DOI: 10.1021/ja01642a036
Tetrahedron Letters, 22, p. 1787, 1981 DOI: 10.1016/S0040-4039(01)90439-3
Biochem/physiol Actions
DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis. Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).
References
1) Dam et al. (2012), Inhibition of cystathione gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity; Eur. J. Pharmacol., 685 165 2) Mok et al. (2004), Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis; Br. J. Pharmacol., 143 881 3) Bhatia et al. (2005),Hydrogen sulphide is a mediator of carrageenan-induced hindpaw edema in the rat; Br. J. Pharmacol., 145 141
DL-PROPARGYLGLYCINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DL-PROPARGYLGLYCINE manufacturers
- Product
- DL-PROPARGYLGLYCINE 64165-64-6
- Price
- US $10.00/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-07-31