ChemicalBook > CAS DataBase List > DL-PROPARGYLGLYCINE

DL-PROPARGYLGLYCINE

Product Name
DL-PROPARGYLGLYCINE
CAS No.
64165-64-6
Chemical Name
DL-PROPARGYLGLYCINE
Synonyms
NSC21940;DL-Pra-OH;H-DL-PRA-OH;H-DL-Prg-OH;DL-PROPARGYL-GLY-OH;DL-PROPARGYLGLYCINE;DL-Gly(Propargyl)-OH;H-PROPARGYL-DL-GLY-OH;H-DL-GLY(PROPARGYL)-OH;H-PROPARGYL-DL-GLYCINE
CBNumber
CB6140609
Molecular Formula
C5H7NO2
Formula Weight
113.11
MOL File
64165-64-6.mol
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DL-PROPARGYLGLYCINE Property

storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml).
form 
Crystalline Powder
color 
White to off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P7888
Product name
DL-Propargylglycine
Purity
cystathionine γ-lyase inhibitor
Packaging
1g
Price
$226
Updated
2024/03/01
Sigma-Aldrich
Product number
P7888
Product name
DL-Propargylglycine
Purity
cystathionine γ-lyase inhibitor
Packaging
5g
Price
$345.2
Updated
2024/03/01
Sigma-Aldrich
Product number
P7888
Product name
DL-Propargylglycine
Purity
cystathionine γ-lyase inhibitor
Packaging
250mg
Price
$77.4
Updated
2024/03/01
Usbiological
Product number
287837
Product name
DL-Propargylglycine
Packaging
500mg
Price
$333
Updated
2021/12/16
Chem-Impex
Product number
07081
Product name
DL-Propargylglycine,≥98%
Purity
≥98%
Packaging
1G
Price
$96.45
Updated
2021/12/16
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DL-PROPARGYLGLYCINE Chemical Properties,Usage,Production

Description

Propargylglycine (64165-64-6) is an irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-γ-lyase. It inhibits H2S production in rat liver preparations (IC50=55 μM) and inhibits the rise in plasma H2S in rats with hemorrhagic shock2. Propargylglycine reduces inflammation in a rodent carrageenan-induced hindpaw edema model3 and ameliorates gentamycin-induced nephrotoxicity1.

Chemical Properties

White to off-white powder

Uses

Dl-propargylglycine is an inhibitor of hydrogen sulfide (H2S) production.

Synthesis Reference(s)

Journal of the American Chemical Society, 76, p. 3484, 1954 DOI: 10.1021/ja01642a036
Tetrahedron Letters, 22, p. 1787, 1981 DOI: 10.1016/S0040-4039(01)90439-3

Biochem/physiol Actions

DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis. Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).

References

1) Dam et al. (2012), Inhibition of cystathione gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity; Eur. J. Pharmacol., 685 165 2) Mok et al. (2004), Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis; Br. J. Pharmacol., 143 881 3) Bhatia et al. (2005),Hydrogen sulphide is a mediator of carrageenan-induced hindpaw edema in the rat; Br. J. Pharmacol., 145 141

DL-PROPARGYLGLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DL-PROPARGYLGLYCINE manufacturers

Career Henan Chemical Co
Product
DL-PROPARGYLGLYCINE 64165-64-6
Price
US $10.00/KG
Min. Order
10KG
Purity
99%
Supply Ability
100kg
Release date
2018-07-31

64165-64-6, DL-PROPARGYLGLYCINERelated Search:

L-Propargylglycine (R)-METHYL-2-BOC-AMINO-4-PENTENOIC ACID (R)-N-BOC-Propargylglycine D-PROPARGYLGLYCINE METHYL-2-BOC-AMINO-4-PENTENOIC ACID (S)-N-BOC-Propargylglycine (R)-2-(((benzyloxy)carbonyl)aMino)pent-4-ynoic acid (S)-2-(((benzyloxy)carbonyl)aMino)pent-4-ynoic acid 4-PENTYNOIC ACID DL-PROPARGYLGLYCINE (S)-ALPHA-PROPYNYL-PROLINE-HCL H-PRA-OME HCL H-GLY-PRO-PNA HCL ACETYL-DL-PROPARGYLGLYCINE ETHYL ESTER H-ASP-PNA HCL (R)-ALPHA-PROPYNYL-PROLINE-HCL (R)-PROPARGYLGLYCINE METHYL ESTER HYDROCHLORIDE N-ACETYL-DL-PROPARGYLGLYCINE

  • H-PROPARGYL-DL-GLYCINE
  • H-PROPARGYL-DL-GLY-OH
  • H-DL-PRA-OH
  • H-DL-GLY(PROPARGYL)-OH
  • DL-PROPARGYLGLYCINE
  • DL-PROPARGYL-GLY-OH
  • 2-AMINO-4-PENTYNOIC ACID
  • NSC21940
  • DL-Propargylglycine hydrochloride
  • DL-Propargylglycine DL-Propargylglycine
  • H-Propargyl-DL-Gly-OH, (RS)-2-AMino-4-pentynoic acid
  • DL-Propargylglycine cystathionine γ-lyase inhibitor
  • DL-Pra-OH
  • DL-Gly(Propargyl)-OH
  • H-DL-Prg-OH
  • DL-PROPARGYLGLYCINE, CYSTATHIONINE G
  • H-DL-Pra-OH DL-Propargylglycine
  • DL-PROPARGYLGLYCINE USP/EP/BP
  • 64165-64-6
  • 16800-57-5
  • BioChemical
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • Modified Amino Acids
  • I - Z
  • Amino Acids