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2-N-HEXYL-4-PENTYNOIC ACID

Product Name
2-N-HEXYL-4-PENTYNOIC ACID
CAS No.
96017-59-3
Chemical Name
2-N-HEXYL-4-PENTYNOIC ACID
Synonyms
Hexyl-4-pentynoic Acid;2-Hexyl-4-pentynoic Acid;2-PROPARGYLOCTANOIC ACID;2-Hexyl-4-pentynoicAcid>2-N-HEXYL-4-PENTYNOIC ACID;2-(2-PROPYNYL)OCTANOIC ACID;Hexyl-4-pentynoic acid (HPA);R-2-(2-propynyl)octanoic acid;2-(2-Propyn-1-yl)octanoic Acid;2-(Prop-2-yn-1-yl)octanoic acid
CBNumber
CB5317246
Molecular Formula
C11H18O2
Formula Weight
182.26
MOL File
96017-59-3.mol
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2-N-HEXYL-4-PENTYNOIC ACID Property

Boiling point:
287.1±23.0 °C(Predicted)
Density 
0.94
refractive index 
1.4450-1.4510
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
pka
4.24±0.21(Predicted)
form 
oil
color 
Colorless
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2916.19.3000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H0964
Product name
2-Hexyl-4-pentynoic Acid
Purity
>95.0%(T)
Packaging
5g
Price
$239
Updated
2024/03/01
TCI Chemical
Product number
H0964
Product name
2-Hexyl-4-pentynoic Acid
Purity
>95.0%(T)
Packaging
25g
Price
$762
Updated
2024/03/01
Cayman Chemical
Product number
15205
Product name
2-hexyl-4-Pentynoic Acid
Purity
≥95%
Packaging
1g
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
15205
Product name
2-hexyl-4-Pentynoic Acid
Purity
≥95%
Packaging
5g
Price
$257
Updated
2024/03/01
Cayman Chemical
Product number
15205
Product name
2-hexyl-4-Pentynoic Acid
Purity
≥95%
Packaging
250mg
Price
$44
Updated
2024/03/01
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2-N-HEXYL-4-PENTYNOIC ACID Chemical Properties,Usage,Production

Description

2-hexyl-4-Pentynoic acid is a derivative of valproic acid , an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 μM) than valproic acid (IC50 = 398 μM). 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 μM. It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 μM.

References

1) Eikel et al. (2006), Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives; Chem. Res. Toxicol., 19 272 2) Leng et al. (2010), Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction; Neurosci. Lett., 476 127

2-N-HEXYL-4-PENTYNOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-N-HEXYL-4-PENTYNOIC ACID Suppliers

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96017-59-3, 2-N-HEXYL-4-PENTYNOIC ACIDRelated Search:

ML234 C 646 5-Azacytidine Entinostat N-HEXYLLITHIUM 1,3,4,6-TETRA-O-ACETYL-2-AZIDO-2-DEOXY-ALPHA-D-MANNOPYRANOSE 4-PENTYNOIC ACID Octanoic acid 4-Pentyn-1-ol 4-Fluorocinnamic acid 2-N-HEXYL-4-PENTYNOIC ACID

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